ArticleJournal of neurology, neurosurgery, and psychiatry2000
Persistence of tropical ataxic neuropathy in a Nigerian community.
Article in Journal of neurology, neurosurgery, and psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Prevalence of ataxia in children: a systematic review.Neurology · 2014Pooled it
- A study on possible risk factors for progressive supranuclear palsy in southern part of India.Current journal of neurology · 2024Article
- Correlate the cyanogenic potential and dry matter content of cassava roots and leaves grown in different environments.Scientific reports · 2023Article
- Burden of adult neurological diseases in Odeda Area, Southwest Nigeria.BMJ neurology open · 2020Article
- Burden, risk factors, and comorbidities of behavioural and emotional problems in Kenyan children: a population-based study.The lancet. Psychiatry · 2017Article
- A Systematic Review of Non-Traumatic Spinal Cord Injuries in Sub-Saharan Africa and a Proposed Diagnostic Algorithm for Resource-Limited Settings.Frontiers in neurology · 2017Review
- A global perspective on the influence of environmental exposures on the nervous system.Nature · 2015Review
- Determinants of cognitive performance in children relying on cyanogenic cassava as staple food.Metabolic brain disease · 2014Article
- Cross-species and tissue variations in cyanide detoxification rates in rodents and non-human primates on protein-restricted diet.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2014Article
- Forward genetics by genome sequencing reveals that rapid cyanide release deters insect herbivory of Sorghum bicolor.Genetics · 2013Article
- Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.International journal of health geographics · 2013Article
- Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava.Pediatrics · 2013Article
- Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.Metabolic brain disease · 2011Review
- Biosynthesis of the cyanogenic glucosides linamarin and lotaustralin in cassava: isolation, biochemical characterization, and expression pattern of CYP71E7, the oxime-metabolizing cytochrome P450 enzyme.Plant physiology · 2011Article
- Nutritional optic and peripheral neuropathy: a case report.Cases journal · 2009Article
- The neurology of enteric disease.Journal of neurology, neurosurgery, and psychiatry · 2006Review
- Article
- Engineering cyanogen synthesis and turnover in cassava (Manihot esculenta).Plant molecular biology · 2004Article
- Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.Journal of neurology, neurosurgery, and psychiatry · 2003Article
- Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants.Plant physiology · 2002Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe term tropical ataxic neuropathy (TAN) is currently used to describe several neurological syndromes attributed to toxiconutritional causes. However, TAN was initially proposed to describe a specific neurological syndrome seen predominantly among the Ijebu speaking Yorubas in south western Nigeria. In this study, the prevalence of TAN was determined in Ososa, a semiurban community in south western Nigeria described as endemic for TAN in 1969, and its neurological features were compared with Strachan's syndrome, prisoners of war neuropathy, the epidemic neuropathy in Cuba, and konzo.
methodsA census of Ososa was followed by door to door screening of all subjects aged 10 years and above with a newly designed screening instrument. Subjects who screened positive had a neurological examination, and the diagnosis of TAN was made if any two or more of bilateral optic atrophy, bilateral neurosensory deafness, sensory gait ataxia, or distal symmetric sensory polyneuropathy were present.
resultsA total of 4583 inhabitants were registered in the census. Of these, 3428 subjects aged 10 years and above were screened. The diagnosis of TAN was made in 206 of 323 subjects who screened positive for TAN. The prevalence of TAN was 6. 0%, 3.9% in males and 7.7% in females. The highest age specific prevalence was 24% in the 60-69 years age group in women.
conclusionThe occurrence of TAN in Ososa continues at a higher prevalence than was reported 30 years ago. Its neurological features and natural history do not resemble those described for Strachan syndrome, epidemic neuropathy in Cuba, or konzo. The increasing consumption of cassava foods linked to its causation makes TAN of public health importance in Nigeria, the most populous African country.
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