ArticleRNA (New York, N.Y.)2000
Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2.
Article in RNA (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- PCB 118 Exposure Modulates Chromatin Organization, Ribosome Biogenesis, and Autophagy-Related Pathways in Neuron-like: A Transcriptomic Analysis.International journal of molecular sciences · 2026Article
- The methyltransferase Rrp8 is a positive regulator of autophagy flux inmicroPublication biology · 2026Article
- RRP8, associated with immune infiltration, is a prospective therapeutic target in hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2024Article
- A Nucleolar Protein, MoRRP8 Is Required for Development and Pathogenicity in the Rice Blast Fungus.Mycobiology · 2023Article
- Chemical Modifications of Ribosomal RNA.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A single NScientific reports · 2018Article
- Yeast screen for modifiers of C9orf72 poly(glycine-arginine) dipeptide repeat toxicity.FEMS yeast research · 2018Article
- PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.Nature communications · 2018Article
- Ribosomal protein and biogenesis factors affect multiple steps during movement of the Saccharomyces cerevisiae Ty1 retrotransposon.Mobile DNA · 2015Article
- SirT1 and rRNA in the nucleolus: regulating the regulator.Oncoscience · 2014Article
- The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP.RNA (New York, N.Y.) · 2013Article
- Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.Nucleic acids research · 2013Article
- A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Genetics · 2012Article
- Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2.Nucleic acids research · 2008Article
- Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins.BMC genomics · 2008Article
- Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast.RNA (New York, N.Y.) · 2008Article
- Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae.Genetics · 2006Article
- hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase.RNA (New York, N.Y.) · 2006Article
- The splicing ATPase prp43p is a component of multiple preribosomal particles.Molecular and cellular biology · 2005Article
- Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.Molecular and cellular biology · 2005Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical modifications and processing of the 18S, 5.8S, and 25S ribosomal RNAs from the 35S pre-ribosomal RNA depend on an important set of small nucleolar ribonucleoprotein particles (snoRNPs). Genetic depletion of yeast Gar1p, an essential common component of H/ACA snoRNPs, leads to inhibition of uridine isomerizations to pseudo-uridines on the 35S pre-rRNA and of the early pre-rRNA cleavages at sites A1 and A2, resulting in a loss of mature 18S rRNA synthesis. To identify Gar1p functional partners, we screened for mutations that are synthetically lethal with a gar1 mutant allele encoding a Gar1p mutant protein lacking its two glycine/arginine-rich (GAR) domains. We identified a previously uncharacterized Saccharomyces cerevisiae open reading frame, YDR083W (now designated RRP8), that encodes a highly conserved protein containing motifs found in methyltransferases. Rrp8p localizes to the nucleolus. A yeast strain lacking this protein is viable at 30 degrees C but displays strong growth impairment at lower temperatures. In this strain, cleavage of the pre-rRNA at site A2 is strongly affected whereas cleavages at sites A0 and A1 are only slightly inhibited or delayed.
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