Evidence map›Paper›PMID 10863944›Full record

ReviewJournal of inherited metabolic disease2000

Lysosomal transport disorders.

G M Mancini, A C Havelaar, F W Verheijen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of inherited metabolic disease, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Lysosomes as a Target of Anticancer Therapy.International journal of molecular sciences · 2023
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. New aspects of the pathogenesis of cystinosis.Pediatric nephrology (Berlin, Germany) · 2003
    Review
  14. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003
    Article
  15. Article
  16. Identification and characterization of a lysosomal transporter for small neutral amino acids.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

G M ManciniDepartment of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands. mancini@kgen.fgg.eur.nl
A C Havelaar
F W Verheijen
Erasmus MC · NLErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the group of lysosomal storage diseases, transport disorders occupy a special place because they represent rare examples of inborn errors of metabolism caused by a defect of an intracellular membrane transporter. In particular, two disorders are caused by a proven defect in carrier-mediated transport of metabolites: cystinosis and the group of sialic acid storage disorders (SASD). The recent identification of the gene mutations for both disorders will improve patient diagnosis and shed light on new physiological mechanisms of intracellular trafficking.

Indexed as

AnimalsBiological TransportCystinosisHumansIntracellular MembranesLysosomal Storage DiseasesLysosomesMucolipidoses

Identifiers

PMID10863944
OpenAlexW1549118128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.