ReviewInternational journal of pancreatology : official journal of the International Association of Pancreatology2000
K-Ras mutations and benign pancreatic disease.
Review in International journal of pancreatology : official journal of the International Association of Pancreatology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.Neoplasia (New York, N.Y.) · 2005Pooled it
- Differentiating Main-Duct IPMN from Chronic Pancreatitis Using Next-Generation Sequencing of Main Pancreatic Duct Fluid: A Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Molecular alterations in pancreatic tumors.World journal of gastroenterology · 2021Review
- Review
- Non-coding RNAs in pancreatic cancer: challenges and opportunities for clinical application.Cellular oncology (Dordrecht, Netherlands) · 2016Review
- MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2.PloS one · 2015Article
- Pancreatic cancer and its stroma: a conspiracy theory.World journal of gastroenterology · 2014Review
- [Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges].Medizinische Klinik (Munich, Germany : 1983) · 2010Article
- Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2009Review
- Mitochondrial DNA mutations in pancreatic cancer.International journal of gastrointestinal cancer · 2006Article
- Management of Patients at High Risk for Pancreatic Cancer.Current treatment options in gastroenterology · 2003Article
- Detection of oncogenes in chronic pancreatitis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2003Article
- Identification of disease-specific genes in chronic pancreatitis using DNA array technology.Annals of surgery · 2001Article
- DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis.Endoscopic ultrasoundArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review addresses the history of the ras oncogene, the techniques used to detect molecular alterations in the ras oncogene, and the application of polymerase chain reaction (PCR)-based methods to determine point mutations in clinical samples of patients with pancreatic diseases, namely pancreatic carcinoma and chronic pancreatitis. The frequency of ras mutations in pancreatic carcinoma is high, ranging from 70 to almost 100%. The frequence of ras mutations in chronic pancreatitis, either in pancreatic tissue or pancreatic secretions, vary between 0 and 100%. This wide range in part may be owing to differences in sampling, DNA extraction, or PCR method. The meaning of a k-ras mutation is under debate. Taking into account the positivity of ductal hyperplasias in normal pancreas and ras mutations in normal appearing duct cells, this molecular finding may not mean anything. In contrast, ras mutations are associated with smoking, one acknowledged risk factor for pancreatic carcinoma. The need for large prospective cohort studies is emphasized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.