Randomized trials or observational tribulations?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

109 citing papers in PubMed, 17 syntheses or guidelines pooled it.

1. The Effects of Pharmacological Treatment of Nightmares: A Systematic Literature Review and Meta-Analysis of Placebo-Controlled, Randomized Clinical Trials.International journal of environmental research and public health · 2022
   Pooled it
2. Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop.BMJ open · 2022
   Pooled it
3. Withholding Feeds and Transfusion-Associated Necrotizing Enterocolitis in Preterm Infants: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017
   Pooled it
4. Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies.Journal of the National Cancer Institute · 2017
   Pooled it
5. Impact of an Early Invasive Strategy versus Conservative Strategy for Unstable Angina and Non-ST Elevation Acute Coronary Syndrome in Patients with Chronic Kidney Disease: A Systematic Review.PloS one · 2016
   Pooled it
6. Clozapine for psychotic disorders in adults with intellectual disabilities.The Cochrane database of systematic reviews · 2015
   Pooled it
7. Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes.European heart journal · 2012
   Pooled it
8. Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2012
   Pooled it
9. Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.PloS one · 2012
   Pooled it
10. Randomisation to protect against selection bias in healthcare trials.The Cochrane database of systematic reviews · 2011
    Pooled it
11. Propensity scores in intensive care and anaesthesiology literature: a systematic review.Intensive care medicine · 2010
    Pooled it
12. The effectiveness and safety of proton radiation therapy for indications of the eye : a systematic review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2009
    Pooled it
13. Use of primary care electronic medical record database in drug efficacy research on cardiovascular outcomes: comparison of database and randomised controlled trial findings.BMJ (Clinical research ed.) · 2009
    Pooled it
14. Azathioprine. Safety profile in multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2007
    Pooled it
15. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings.American journal of infection control · 2007
    Guideline
16. Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis.Arthritis research & therapy · 2006
    Pooled it
17. Artificial and bioartificial support systems for liver failure.The Cochrane database of systematic reviews · 2004
    Pooled it
18. Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes.Journal of the American Heart Association · 2021
    Trial
19. Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study.Clinical research in cardiology : official journal of the German Cardiac Society · 2012
    Trial
20. Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study.PloS one · 2012
    Trial

49 more citing papers are in PubMed but not listed here.

Corrections and comments

• Commented on by
  Observational studies and randomized trials.2000
• Comment on
  A comparison of observational studies and randomized, controlled trials.2000
• Comment on
  Randomized, controlled trials, observational studies, and the hierarchy of research designs.2000

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as