ReviewGut2000
Inducible nitric oxide synthase: a little bit of good in all of us.
Review in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 126 citations in OpenAlex.
- Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions.Digestive diseases and sciences · 2005Trial
- Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2026Review
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Genomics and Histopathology in Interstitial Cystitis/Bladder Pain Syndrome.Neurourology and urodynamics · 2026Review
- Anti-Inflammatory Effects ofLife (Basel, Switzerland) · 2025Article
- Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis.World journal of gastroenterology · 2022Article
- The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis.Antioxidants (Basel, Switzerland) · 2022Review
- Oxidative stress and visual system: a review.EXCLI journal · 2022Review
- Article
- Activation of the iNOS/NO/cGMP pathway by Revactin® in human corporal smooth muscle cells.Translational andrology and urology · 2021Article
- Tristetraprolin targets Nos2 expression in the colonic epithelium.Scientific reports · 2019Article
- Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer.Cell reports · 2018Article
- Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum.Pharmaceutical biology · 2017Article
- Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by an iNOS-dependent increase in nitric oxide availability.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen.International journal of immunopathology and pharmacology · 2017Article
- Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice.World journal of gastroenterology · 2015Article
- NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Biomolecular Modulation of Neurodegenerative Events during Ageing.Oxidative medicine and cellular longevity · 2015Article
- Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The established dogma regarding the different isoforms of nitric oxide has been that constitutively expressed nitric oxide synthase is an extremely important homeostatic regulator of numerous important physiological processes whereas the inducible form of nitric oxide synthase underlies injury associated with intestinal inflammation. In this brief overview, I review some of the literature that clearly supports this contention, particularly the dramatically beneficial effects of oral L-NAME administration to animals with colitis induced by trinitrobenzene sulphonic acid (TNBS). However, I also highlight some of the gastrointestinal data that does not fit this simple tidy paradigm, particularly with respect to the inducible form of nitric oxide synthase (iNOS). For example, iNOS induced healing of skin and the intestinal mucosa, killing of certain bacteria, regulation of T cell proliferation and differentiation (Th1 v Th2), and control of leucocyte recruitment may mask or counter the toxic metabolites that are produced by iNOS. Perhaps it is not surprising that one does not always obtain benefit from inhibiting all iNOS either by gene deletion or by systemic NOS inhibition. I raise some potential flaws in our approaches to studying iNOS. For example, to date no attempts have been made to selectively inhibit iNOS in single cell types. Global inhibition of all iNOS assumes that the large variety of cell types that can produce iNOS have identical functions. Finally, I attempt to highlight areas that require additional investigation and issues that have not been explored.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.