ArticleThe Biochemical journal2000
p40(phox) Participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558).
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Mechanistic computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly and activation facilitating superoxide production.Free radical research · 2020Article
- A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production.Free radical biology & medicine · 2019Article
- NADPH oxidases: an overview from structure to innate immunity-associated pathologies.Cellular & molecular immunology · 2015Review
- Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases.Physiological reviews · 2014Review
- Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors.Cellular and molecular life sciences : CMLS · 2012Review
- Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.Circulation research · 2012Review
- NOX and inflammation in the vascular adventitia.Free radical biology & medicine · 2009Article
- DNase I inhibits a late phase of reactive oxygen species production in neutrophils.Journal of innate immunity · 2009Article
- Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase.The Journal of biological chemistry · 2008Article
- Regulation of Nox and Duox enzymatic activity and expression.Free radical biology & medicine · 2007Review
- A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Molecular biology of the cell · 2007Article
- The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.The Journal of experimental medicine · 2006Article
- Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.The Journal of experimental medicine · 2006Article
- Activation and assembly of the NADPH oxidase: a structural perspective.The Biochemical journal · 2005Review
- Assembly of the phagocyte NADPH oxidase.Histochemistry and cell biology · 2004Review
- The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.Biochimica et biophysica acta · 2004Review
- Gene expression versus sequence for predicting function: Glia Maturation Factor gamma is not a glia maturation factor.Genomics, proteomics & bioinformatics · 2003Article
- The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
NADPH oxidase is one of the major components of the innate immune system and is used by phagocytes to generate microbicidal reactive oxygen species. Activation of the enzyme requires the participation of a minimum of five proteins, p22(phox), gp91(phox) (together forming flavocytochrome b(558)), p47(phox), p67(phox) and the GTP-binding protein, Rac2. A sixth protein, p40(phox), has been implicated in the control of the activity of NADPH oxidase principally based on its sequence homology to, and physical association with, other phox components, and also the observation that it is phosphorylated during neutrophil activation. However, to date its role in regulating the activity of the enzyme has remained obscure, with evidence for both positive and negative influences on oxidase activity having being reported. Data are presented here using the cell-free system for NADPH oxidase activation that shows that p40(phox) can function to promote oxidase activation by increasing the affinity of p47(phox) for the enzyme approx. 3-fold.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.