ArticleProceedings of the National Academy of Sciences of the United States of America2000
Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 197 citations in OpenAlex.
- Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2Brain and behavior · 2026Article
- Steroid receptor coactivator-1: integrating steroid hormone signals to regulate brain function and disease.Frontiers in neuroscience · 2026Review
- A bifunctional optical reporter for tracking estrogen response dynamics in neurons.bioRxiv : the preprint server for biology · 2025Article
- Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy.Critical reviews in immunology · 2024Review
- CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.Scientific reports · 2023Article
- Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.Journal of neuro-oncology · 2023Article
- Steroid receptor coactivator-1: The central intermediator linking multiple signals and functions in the brain and spinal cord.Genes & diseases · 2022Review
- Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers.Biology of sex differences · 2022Article
- Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory.Neuroscience bulletin · 2021Article
- SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS.Neurochemical research · 2021Article
- Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence.Sexual medicine · 2021Article
- The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?Frontiers in cellular neuroscience · 2021Review
- Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.Endocrinology · 2020Review
- Scaffold attachment factor B: distribution and interaction with ERα in the rat brain.Histochemistry and cell biology · 2020Article
- Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review.British journal of anaesthesia · 2020Review
- How technical progress reshaped behavioral neuroendocrinology during the last 50 years… and some methodological remarks.Hormones and behavior · 2020Review
- New concepts in the study of the sexual differentiation and activation of reproductive behavior, a personal view.Frontiers in neuroendocrinology · 2019Review
- Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: considerations for future research.Nutrition reviews · 2018Review
- Oral administration of titanium dioxide nanoparticle through ovarian tissue alterations impairs mice embryonic development.International journal of reproductive biomedicine · 2018Article
- Steroids and the brain: 50years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions.Hormones and behavior · 2018Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.