Evidence map›Paper›PMID 10861004›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2000

Recent common ancestry of human Y chromosomes: evidence from DNA sequence data.

R Thomson, J K Pritchard, P Shen, P J Oefner, M W Feldman

Abstract readComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  7. Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

R ThomsonDepartment of Integrative Biology, University of California, Berkeley, CA 94720, USA.
J K Pritchard
P Shen
P J Oefner
M W Feldman

Funding

VARIATIONS OF HUMAN DNA SEQUENCESP01GM028428 · NIGMS · STANFORD UNIVERSITY · PI CAVALLI-SFORZA, LUIGI L · 1985 to 2004
$6.8M
POPULATION GENETICS THEORYR01GM028016 · NIGMS · STANFORD UNIVERSITY · PI FELDMAN, MARCUS W · 1985 to 2010
$2.5M
NIGMS NIH HHS GM28016NIGMS NIH HHS GM28428NIGMS NIH HHS P01 GM028428NIGMS NIH HHS R01 GM028016Wellcome Trust
6 · The paper itself

Abstract

We consider a data set of DNA sequence variation at three Y chromosome genes (SMCY, DBY, and DFFRY) in a worldwide sample of human Y chromosomes. Between 53 and 70 chromosomes were fully screened for sequence variation at each locus by using the method of denaturing high-performance liquid chromatography. The sum of the lengths of the three genes is 64,120 bp. We have used these data to study the ancestral genealogy of human Y chromosomes. In particular, we focused on estimating the expected time to the most recent common ancestor and the expected ages of certain mutations with interesting geographic distributions. Although the geographic structure of the inferred haplotype tree is reminiscent of that obtained for other loci (the root is in Africa, and most of the oldest non-African lineages are Asian), the expected time to the most recent common ancestor is remarkably short, on the order of 50,000 years. Thus, although previous studies have noted that Y chromosome variation shows extreme geographic structure, we estimate that the spread of Y chromosomes out of Africa is much more recent than previously was thought. We also show that our data indicate substantial population growth in the effective number of human Y chromosomes.

Indexed as

Biological EvolutionPolymorphism, GeneticY ChromosomeGenetic VariationHumansMaleSequence Analysis, DNA

Identifiers

PMID10861004
PMCPMC16550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.