ArticleProceedings of the National Academy of Sciences of the United States of America2000
Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Elevated third trimester corticosteroid levels are associated with fewer offspring infections.Scientific reports · 2023Article
- Review
- Developmental Programming by Perinatal Glucocorticoids.Molecules and cells · 2022Review
- Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids.Acta pharmacologica Sinica · 2022Article
- Glucocorticoids in T cell development, differentiation and function.Nature reviews. Immunology · 2021Review
- Article
- Maternal-Fetal Circadian Communication During Pregnancy.Frontiers in endocrinology · 2020Review
- Steroids, Pregnancy and Fetal Development.Frontiers in immunology · 2019Review
- Dark shadow of the long white cloud: Neighborhood safety is associated with self-rated health and cortisol during pregnancy in Auckland,SSM - population health · 2017Article
- Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior.Translational psychiatry · 2017Article
- Maternal bile acid transporter deficiency promotes neonatal demise.Nature communications · 2015Article
- Glucocorticoid regulation of lung development: lessons learned from conditional GR knockout mice.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Differential subcellular localization of the glucocorticoid receptor in distinct neural stem and progenitor populations of the mouse telencephalon in vivo.Brain research · 2013Article
- Corticotropin-releasing hormone exerts direct effects on neuronal progenitor cells: implications for neuroprotection.Molecular psychiatry · 2013Article
- Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression.Endocrinology · 2012Article
- Antenatal corticosteroids: a risk factor for the development of chronic disease.Journal of nutrition and metabolism · 2012Article
- Chronic stress in pregnant guinea pigs (Cavia aperea f. porcellus) attenuates long-term stress hormone levels and body weight gain, but not reproductive output.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Diurnal rhythm of cortisol during late pregnancy: associations with maternal psychological well-being and fetal growth.Psychoneuroendocrinology · 2008Article
- Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis, including hypothalamic corticotropin-releasing hormone (CRH) and pituitary corticotropin, is one of the first endocrine systems to develop during fetal life, probably because glucocorticoid secretion is necessary for the maturation of many essential fetal organs. Consistent with this, pregnant mice with an inactivating mutation in the Crh gene deliver CRH-deficient offspring that die at birth with dysplastic lungs, which can be prevented by prenatal maternal glucocorticoid treatment. But children lacking the ability to synthesize cortisol (because of various genetic defects in adrenal gland development or steroidogenesis) are not born with respiratory insufficiency or abnormal lung development, suggesting that the transfer of maternal glucocorticoid across the placenta might promote fetal organ maturation in the absence of fetal glucocorticoid production. We used pregnant mice with a normal HPA axis carrying fetuses with CRH deficiency to characterize the relative contributions of the fetal and maternal adrenal to the activity of the fetal HPA axis, and related these findings to fetal lung development. We found that in the presence of fetal adrenal insufficiency, normal fetal lung development is maintained by the transfer of maternal glucocorticoid to the fetus, specifically during the circadian peak in maternal glucocorticoid secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.