ArticleProceedings of the National Academy of Sciences of the United States of America2000
Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
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- Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury.Frontiers in cell and developmental biology · 2021Article
- Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ.Molecular cancer · 2017Article
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- Alternative splicing tends to avoid partial removals of protein-protein interaction sites.BMC genomics · 2013Article
- Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- The therapeutic potential of RORγ modulators in the treatment of human disease.Journal of experimental pharmacology · 2012Review
- Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex.Cellular and molecular neurobiology · 2010Article
- Bioinformatic flowchart and database to investigate the origins and diversity of clan AA peptidases.Biology direct · 2009Article
- Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.Nuclear receptor signaling · 2009Review
- Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.Nature neuroscience · 2007Article
- Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development.Advances in developmental biology (Amsterdam, Netherlands) · 2006Article
- NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.Genes & development · 2005Article
- Nuclear receptor coregulators are new players in nervous system development and function.Molecular neurobiology · 2004Review
- ERAP140, a conserved tissue-specific nuclear receptor coactivator.Molecular and cellular biology · 2002Article
- X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.The EMBO journal · 2001Article
- Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells.Nucleic acids research · 2001Article
- Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptors are transcription factors that require multiple protein-protein interactions to regulate target gene expression. We have cloned a 27-kDa protein, termed NIX1 (neuronal interacting factor X 1), that directly binds nuclear receptors in vitro and in vivo. Protein-protein interaction between NIX1 and ligand-activated or constitutive active nuclear receptors, including retinoid-related orphan receptor beta (RORbeta) (NR1F2), strictly depends on the conserved receptor C-terminal activation function 2 (AF2-D). NIX1 selectively binds retinoic acid receptor (RAR) (NR1A) and thyroid hormone receptor (TR) (NR1B) in a ligand-dependent manner, but does not interact with retinoid X receptor (RXR) (NR2B) or steroid hormone receptors. Interestingly, NIX1 down-regulates transcriptional activation by binding to ligand-bound nuclear receptors. A 39-aa domain within NIX1 was found to be necessary and sufficient for protein-protein interactions with nuclear receptors. Northern blot analysis demonstrates low-abundance RNA messages only in brain and neuronal cells. In situ hybridization and immunohistochemistry revealed that NIX1 expression is restricted to the central nervous system and could be confined to neurons in the dentate gyrus of the hippocampus, the amygdala, thalamic, and hypothalamic regions. In summary, protein-protein interactions between the neuronal protein NIX1 and ligand-activated nuclear receptors are both specific and selective. By suppressing receptor-mediated transcription, NIX1 implements coregulation of nuclear receptor functions in brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.