ArticleProceedings of the National Academy of Sciences of the United States of America2000
Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Influence of nutrition on infection and re-infection with soil-transmitted helminths: a systematic review.Parasites & vectors · 2014Pooled it
- Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.Advances in parasitology · 2024Article
- Identification of potential biomarkers in malnutrition children with severity byEuropean journal of nutrition · 2023Article
- Embracing nature's complexity: Immunoparasitology in the wild.Seminars in immunology · 2021Review
- Supplemented nutrition decreases helminth burden and increases drug efficacy in a natural host-helminth system.Proceedings. Biological sciences · 2021Article
- Reviewing the effects of food provisioning on wildlife immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The Immune and Non-Immune Pathways That Drive Chronic Gastrointestinal Helminth Burdens in the Wild.Frontiers in immunology · 2018Article
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
- Parasites, nutrition, immune responses and biology of metabolic tissues.Parasite immunology · 2017Review
- Feeding Immunity: Physiological and Behavioral Responses to Infection and Resource Limitation.Frontiers in immunology · 2017Article
- Effects of protein malnutrition on tolerance to helminth infection.Biology letters · 2016Article
- Fidelity in Animal Modeling: Prerequisite for a Mechanistic Research Front Relevant to the Inflammatory Incompetence of Acute Pediatric Malnutrition.International journal of molecular sciences · 2016Review
- Quadruple burden of HIV/AIDS, tuberculosis, chronic intestinal parasitoses, and multiple micronutrient deficiency in ethiopia: a summary of available findings.BioMed research international · 2015Review
- Evaluation of biochemical, hematological and parasitological parameters of protein-deficient hamsters infected with Ancylostoma ceylanicum.PLoS neglected tropical diseases · 2014Article
- Article
- Selenium status alters the immune response and expulsion of adult Heligmosomoides bakeri worms in mice.Infection and immunity · 2013Article
- Enteric pathogens through life stages.Frontiers in cellular and infection microbiology · 2012Review
- Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana.BMC public health · 2011Article
- Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: patterns of malaria coinfection, anemia, and albendazole treatment failure.The American journal of tropical medicine and hygiene · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein malnutrition may increase susceptibility to gastrointestinal parasitic infections, possibly as a result of impaired intestinal and/or systemic T helper 2 (Th2) effector responses induced by down-regulation of Th2 cytokines and/or up-regulation of Th1 cytokines. To test this hypothesis, female BALB/c mice (n = 18/diet) were fed a control (24%), marginal (7%), or deficient (3%) protein diet and given a challenge infection with Heligmosomoides polygyrus. The 3% mice had higher worm burdens at 1, 2, and 4 weeks postchallenge infection (pci), lower increases in serum IgE, reduced intestinal eosinophilia, and depressed mucosal mast cell proliferation and activation at 1-2 weeks pci. To determine whether these suppressed effector responses resulted from altered spleen and mesenteric lymph node (MLN) cytokine production, cells were restimulated in vitro with parasite antigen and cytokine concentrations were measured. Deficient MLN cells secreted significantly less IL-4 and more IFN-gamma at 1-2 weeks pci than did control MLN cells. Deficient spleen cells also secreted more IFN-gamma at 2 weeks pci compared with control spleen cells. From reverse transcription-PCR analyses, the 3% mice also had lower IL-4 mRNA level in spleen and MLN at 1-2 weeks pci. Our study supports the hypothesis that protein malnutrition increases the survival of a nematode parasite by decreasing gut-associated IL-4 (Th2) and increasing IFN-gamma (Th1) within 2 weeks pci, leading to reduced intestinal and systemic Th2 effector responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.