ReviewProceedings of the National Academy of Sciences of the United States of America2000
Population structure and recent evolution of Plasmodium falciparum.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 153 citations in OpenAlex.
- The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy.NPJ vaccines · 2025Review
- High Prevalence ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- High transmission efficiency of the simian malaria vectors and population expansion of their parasites Plasmodium cynomolgi and Plasmodium inui.PLoS neglected tropical diseases · 2023Article
- Article
- Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso.Parasites & vectors · 2020Article
- Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea.The Korean journal of parasitology · 2018Review
- Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT.Malaria journal · 2018Article
- A bite to fight: front-line innate immune defenses against malaria parasites.Pathogens and global health · 2018Review
- Molecular characterization ofThe Indian journal of medical research · 2017Article
- Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice.Malaria journal · 2016Article
- Molecular basis of human cerebral malaria development.Tropical medicine and health · 2016Review
- Merozoite surface protein-1 genetic diversity in Plasmodium malariae and Plasmodium brasilianum from Brazil.BMC infectious diseases · 2015Article
- Diversity of malaria parasites in great apes in Gabon.Malaria journal · 2015Article
- Five-year tracking of Plasmodium falciparum allele frequencies in a holoendemic area with indistinct seasonal transitions.Journal of multidisciplinary healthcare · 2014Article
- Article
- Malarial parasite diversity in chimpanzees: the value of comparative approaches to ascertain the evolution of Plasmodium falciparum antigens.Malaria journal · 2013Article
- Repeat or not repeat?--Statistical validation of tandem repeat prediction in genomic sequences.Nucleic acids research · 2012Article
- Genetic diversity in merozoite surface protein-1 and 2 among Plasmodium falciparum isolates from malarious districts of tribal dominant state of Jharkhand, India.Annals of tropical medicine and parasitology · 2011Article
- Article
- Variable numbers of tandem repeats in Plasmodium falciparum genes.Journal of molecular evolution · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodium falciparum is the agent of malignant malaria, one of mankind's most severe maladies. The parasite exhibits antigenic polymorphisms that have been postulated to be ancient. We have proposed that the extant world populations of P. falciparum have derived from one single parasite, a cenancestor, within the last 5, 000-50,000 years. This inference derives from the virtual or complete absence of synonymous nucleotide polymorphisms at genes not involved in immune or drug responses. Seeking to conciliate this claim with extensive antigenic polymorphism, we first note that allele substitutions or polymorphisms can arise very rapidly, even in a single generation, in large populations subject to strong natural selection. Second, new alleles can arise not only by single-nucleotide mutations, but also by duplication/deletion of short simple-repeat DNA sequences, a process several orders of magnitude faster than single-nucleotide mutation. We analyze three antigenic genes known to be extremely polymorphic: Csp, Msp-1, and Msp-2. We identify regions consisting of tandem or proximally repetitive short DNA sequences, including some previously unnoticed. We conclude that the antigenic polymorphisms are consistent with the recent origin of the world populations of P. falciparum inferred from the analysis of nonantigenic genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.