ArticleProceedings of the National Academy of Sciences of the United States of America2000
Genome-wide scan for body composition in pigs reveals important role of imprinting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 295 citations in OpenAlex.
- Parent-of-origin effects in sheep: impact on the data fit, explanatory power of the model and theoretical accuracy of the breeding values.Scientific reports · 2026Article
- Identification of Monoallelically Expressed Genes Associated with Economic Traits in Hanwoo (Korean Native Cattle).Animals : an open access journal from MDPI · 2021Article
- Antagonistic maternal and direct effects of the leptin receptor gene on body weight in pigs.PloS one · 2021Article
- Modification of Experimental Design and Statistical Method for Mapping Imprinted QTLs Based on Immortalized FFrontiers in genetics · 2020Article
- Analysis of allele-specific expression using RNA-seq of the Korean native pig and Landrace reciprocal cross.Asian-Australasian journal of animal sciences · 2019Article
- Evolutionary Quantitative Genetics of Genomic Imprinting.Genetics · 2019Article
- Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse.Scientific reports · 2017Article
- Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.PLoS genetics · 2015Article
- Accuracy of estimated breeding values with genomic information on males, females, or both: an example on broiler chicken.Genetics, selection, evolution : GSE · 2015Article
- Genomic imprinting effects on complex traits in domesticated animal species.Frontiers in genetics · 2015Review
- A model for family-based case-control studies of genetic imprinting and epistasis.Briefings in bioinformatics · 2014Article
- Muscle transcriptomic investigation of late fetal development identifies candidate genes for piglet maturity.BMC genomics · 2014Article
- Article
- Paternal allele influences high fat diet-induced obesity.PloS one · 2014Article
- Analysis of the associations between polymorphisms in GNAS complex locus and growth, carcass and meat quality traits in pigs.Molecular biology reports · 2013Article
- A least squares regression model to detect quantitative trait Loci with polar overdominance in a cross of outbred breeds: simulation.Asian-Australasian journal of animal sciences · 2013Article
- Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects.BMC genetics · 2013Article
- Quantitative trait loci affecting response to crowding stress in an F(2) generation of rainbow trout produced through phenotypic selection.Marine biotechnology (New York, N.Y.) · 2013Article
- Genomic imprinting and parent-of-origin effects on complex traits.Nature reviews. Genetics · 2013Review
- Parametric proportional hazards model for mapping genomic imprinting of survival traits.Journal of applied genetics · 2013Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of imprinting in body composition was investigated in an experimental cross between Chinese Meishan pigs and commercial Dutch pigs. A whole-genome scan revealed significant evidence for five quantitative trait loci (QTL) affecting body composition, of which four were imprinted. Imprinting was tested with a statistical model that separated the expression of paternally and maternally inherited alleles. For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7. In the same region of SSC7, a maternally expressed QTL affecting muscle depth was found. Chromosome 6 harbored a maternally expressed QTL on the short arm and a paternally expressed QTL on the long arm, both affecting intramuscular fat content. The individual QTL explained from 2% up to 10% of the phenotypic variance. The known homologies to human and mouse did not reveal positional candidate genes. This study demonstrates that testing for imprinting should become a standard procedure to unravel the genetic control of multifactorial traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.