ArticleThe Journal of experimental medicine2000
Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 116 citations in OpenAlex.
- Addressing the role of PKD3 in the T cell compartment with knockout mice.Cell communication and signaling : CCS · 2022Article
- New insights into the Vav1 activation cycle in lymphocytes.Cellular signalling · 2018Article
- Protein kinase D1 (PKD1) phosphorylation on SerThe Journal of biological chemistry · 2017Article
- Protein kinase D regulates positive selection of CD4Nature communications · 2016Article
- VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production.Molecular and cellular endocrinology · 2016Article
- Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.Cell death and differentiation · 2016Article
- Serine-threonine kinases in TCR signaling.Nature immunology · 2014Review
- A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling.European journal of immunology · 2013Article
- Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms.Cell communication and signaling : CCS · 2013Article
- Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues.European journal of immunology · 2012Article
- X-box binding protein 1 induces the expression of the lytic cycle transactivator of Kaposi's sarcoma-associated herpesvirus but not Epstein-Barr virus in co-infected primary effusion lymphoma.The Journal of general virology · 2011Article
- Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts.The Journal of biological chemistry · 2011Article
- Regulation of Syk by phosphorylation on serine in the linker insert.The Journal of biological chemistry · 2010Article
- Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.The Biochemical journal · 2010Article
- CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.Biochemical and biophysical research communications · 2010Article
- Function of the nucleotide exchange activity of vav1 in T cell development and activation.Science signaling · 2009Article
- Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis.Molecules and cells · 2009Review
- Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot.Nature cell biology · 2009Article
- Characterization of EVL-I as a protein kinase D substrate.Cellular signalling · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Protein kinase Cs (PKCs) are activated by antigen receptors in lymphocytes, but little is known about proximal targets for PKCs in antigen receptor-mediated responses. In this report, we define a role for diacylglycerol-regulated PKC isoforms in controlling the activity of the serine/threonine kinase protein kinase D (PKD; also known as PKC mu) in T cells, B cells, and mast cells. Antigen receptor activation of PKD is a rapid and sustained response that can be seen in T cells activated via the T cell antigen receptor, B cells activated via the B cell antigen receptor, and in mast cells triggered via the high-affinity receptor for IgE (FcepsilonR1). Herein, we show that antigen receptor activation of PKD requires the activity of classical/novel PKCs. Moreover, PKC activity is sufficient to bypass the requirement for antigen receptor signals in the induction of PKD activity. These biochemical and genetic studies establish a role for antigen receptor-regulated PKC enzymes in the control of PKD activity. Regulation of PKD activity through upstream PKCs reveals a signaling network that exists between different members of the PKC superfamily of kinases that can operate to amplify and disseminate antigen receptor signals generated at the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.