ArticleThe Journal of experimental medicine2000
Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 125 citations in OpenAlex.
- Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis.Journal of advanced research · 2022Article
- Analysis of prognostic factors in 171 patients with myxofibrosarcoma of the trunk and extremities: a cohort study.Annals of translational medicine · 2021Article
- Emerging Pathological Engagement of Ferroptosis in Gut Diseases.Oxidative medicine and cellular longevity · 2021Review
- Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis.Mucosal immunology · 2018Article
- Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid.Molecules (Basel, Switzerland) · 2017Article
- Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.Frontiers in immunology · 2015Review
- CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells.Frontiers in immunology · 2015Review
- Effect of the alcohol consumption on osteocyte cell processes: a molecular imaging study.Journal of cellular and molecular medicine · 2014Article
- Hyaluronan, a crucial regulator of inflammation.Frontiers in immunology · 2014Review
- ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis.The Journal of biological chemistry · 2013Article
- Gottron's papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature.The Journal of investigative dermatology · 2012Article
- CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients.Experimental and therapeutic medicine · 2012Article
- Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44.Frontiers in immunology · 2012Article
- Identification of specific chondroitin sulfate species in cutaneous autoimmune disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Multifaceted regulation of T cells by CD44.Communicative & integrative biology · 2010Article
- CD44 regulates survival and memory development in Th1 cells.Immunity · 2010Article
- The role of CD44 in cutaneous inflammation.Experimental dermatology · 2009Article
- Osteopontin as two-sided mediator of intestinal inflammation.Journal of cellular and molecular medicine · 2009Article
- CD44 deficiency attenuates chronic murine ileitis.Gastroenterology · 2008Article
- Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications.Gut · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental colitis in mice is characterized by infiltration of activated T helper (Th) cells and macrophages into the lamina propria. Particularly, these cells expressed CD44 variant exon 7 (CD44v7)-containing isoforms. Upregulation of CD44v7 isoforms was induced by CD40 ligation, an inflammation-driving interaction between activated Th cells and macrophages. To define the role of CD44v7 in colitis, mice bearing a targeted deletion for exon v7 were generated. In trinitrobenzene sulfonic acid-induced colitis, wild-type mice developed severe signs of persistent inflammation. Mice lacking CD44v7 initially showed unspecific inflammation, then recovered completely. The pathogenic origin was shown to reside in bone marrow-derived CD44v7(+) cells, because adoptive transfer experiments demonstrated an absolute requirement for CD44v7 on hematopoietic cells for maintenance of colitis. Interleukin (IL)-10-deficient mice, which develop a chronic Th1-driven enterocolitis, were crossbred with CD44v6/v7 null mice. In IL-10 x CD44v6/v7 double deficient mice, intestinal inflammation developed only weakly and at an older age. Analysis of cell death in the inflamed lesions revealed that mononuclear cells in the CD44v7 null infiltrates had higher rates of apoptosis than those from wild-type mice. Thus, the region encoded by CD44v7 appears to be essential for survival of effector lymphocytes, resulting in persistence of inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.