ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2000
Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).
Article in American journal of physiology. Gastrointestinal and liver physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Sorting of complex sphingolipids within the cellular endomembrane systems.Frontiers in cell and developmental biology · 2024Review
- Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels.Disease models & mechanisms · 2017Article
- Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins.Frontiers in physiology · 2015Article
- Functions of cholera toxin B-subunit as a raft cross-linker.Essays in biochemistry · 2015Article
- Intestinal caveolin-1 is important for dietary fatty acid absorption.Biochimica et biophysica acta · 2013Article
- ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipids.Gastroenterology · 2008Article
- Asymmetric localization of calpain 2 during neutrophil chemotaxis.Molecular biology of the cell · 2007Article
- Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells.The EMBO journal · 2004Article
- Deep-apical tubules: dynamic lipid-raft microdomains in the brush-border region of enterocytes.The Biochemical journal · 2003Article
- Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathway.Infection and immunity · 2002Article
- Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells.Molecular and cellular biology · 2002Article
- Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84.Infection and immunity · 2001Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
In intestinal epithelia, cholera and related toxins elicit a cAMP-dependent chloride secretory response fundamental to the pathogenesis of toxigenic diarrhea. We recently proposed that specificity of cholera toxin (CT) action in model intestinal epithelia may depend on the toxin's cell surface receptor ganglioside G(M1). Binding G(M1) enabled the toxin to elicit a response, but forcing the toxin to enter the cell by binding the closely related ganglioside G(D1a) rendered the toxin inactive. The specificity of ganglioside function correlated with the ability of G(M1) to partition CT into detergent-insoluble glycosphingolipid-rich membranes (DIGs). To test the biological plausibility of these hypotheses, we examined native human intestinal epithelia. We show that human small intestinal epithelia contain DIGs that distinguish between toxin bound to G(M1) and G(D1a), thus providing a possible mechanism for enterotoxicity associated with CT. We find direct evidence for the presence of caveolin-1 in DIGs from human intestinal epithelia but find that these membranes are heterogeneous and that caveolin-1 is not a structural component of apical membrane DIGs that contain CT.
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