ArticleAmerican journal of human genetics2000
The problems of using the transmission/disequilibrium test to infer tight linkage.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Excess of transmission of the G allele of the -1438A/G polymorphism of the 5-HT2A receptor gene in patients with schizophrenia responsive to antipsychotics.BMC psychiatry · 2008Article
- Article
- Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations.Genetics · 2002Article
- Interpretation of genetic association studies in complex disease.The pharmacogenomics journal · 2002Review
- Multipoint linkage-disequilibrium-mapping approach based on the case-parent trio design.American journal of human genetics · 2001Article
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3 authors.
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Abstract
Family-based association methods such as the transmission/disequilibrium test (TDT) have become very popular during the past few years, often being preferred to case-control studies because family-based approaches avoid the difficulties of ascertainment of appropriate populations of cases and controls for case-control studies. Significant TDT results indicate both linkage and allelic association. However, significant TDT results are often interpreted as implying tight linkage of marker and disease locus, and we shall argue here that, in general, this interpretation is not justified.
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