ArticleInfection and immunity2000
The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Erp and Rev Adhesins of the Lyme Disease Spirochete's Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection.Infection and immunity · 2023Review
- Large-Scale Sequencing ofGenes · 2022Review
- Pathogenesis of Relapsing Fever.Current issues in molecular biology · 2021Review
- Primordial origin and diversification of plasmids in Lyme disease agent bacteria.BMC genomics · 2018Article
- Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies forFrontiers in immunology · 2017Review
- The Borrelia burgdorferi telomere resolvase, ResT, anneals ssDNA complexed with its cognate ssDNA-binding protein.Nucleic acids research · 2016Article
- BorreliaBase: a phylogeny-centered browser of Borrelia genomes.BMC bioinformatics · 2014Article
- Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci.Applied and environmental microbiology · 2013Article
- Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.Ticks and tick-borne diseases · 2013Review
- Borrelia burgdorferi cp32 BpaB modulates expression of the prophage NucP nuclease and SsbP single-stranded DNA-binding protein.Journal of bacteriology · 2012Article
- BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins.Journal of bacteriology · 2012Article
- Relapsing fever spirochetes retain infectivity after prolonged in vitro cultivation.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2008Article
- Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection.International journal of medical microbiology : IJMM · 2008Review
- Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids.Molecular microbiology · 2006Article
- Borrelia burgdorferi EbfC, a novel, chromosomally encoded protein, binds specific DNA sequences adjacent to erp loci on the spirochete's resident cp32 prophages.Journal of bacteriology · 2006Article
- Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America.Infection and immunity · 2005Article
- Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida.Journal of clinical microbiology · 2005Article
- Whole-genome DNA array analysis of the response of Borrelia burgdorferi to a bactericidal monoclonal antibody.Infection and immunity · 2004Article
- Borrelia outer membrane surface proteins and transmission through the tick.The Journal of experimental medicine · 2004Review
- Intra- and interbacterial genetic exchange of Lyme disease spirochete erp genes generates sequence identity amidst diversity.Journal of molecular evolution · 2003Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Borrelia hermsii, an agent of tick-borne relapsing fever, was found to contain multiple circular plasmids approximately 30 kb in size. Sequencing of a DNA library constructed from circular plasmid fragments enabled assembly of a composite DNA sequence that is homologous to the cp32 plasmid family of the Lyme disease spirochete, B. burgdorferi. Analysis of another relapsing fever bacterium, B. parkeri, indicated that it contains linear homologs of the B. hermsii and B. burgdorferi cp32 plasmids. The B. hermsii cp32 plasmids encode homologs of the B. burgdorferi Mlp and Bdr antigenic proteins and BlyA/BlyB putative hemolysins, but homologs of B. burgdorferi erp genes were absent. Immunoblot analyses demonstrated that relapsing fever patients produced antibodies to Mlp proteins, indicating that those proteins are synthesized by the spirochetes during human infection. Conservation of cp32-encoded genes in different Borrelia species suggests that their protein products serve functions essential to both relapsing fever and Lyme disease spirochetes. Relapsing fever borreliae replicate to high levels in the blood of infected animals, permitting direct detection and possible functional studies of Mlp, Bdr, BlyA/BlyB, and other cp32-encoded proteins in vivo.
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