Association between SSRIs and upper gastrointestinal bleeding. SSRIs are no more likely than other drugs to cause such bleeding.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Risk of gastrointestinal bleeding by specific SSRIs and SNRIs: A systematic review and meta-analysis.British journal of clinical pharmacology · 2026
   Pooled it
2. Early steps in the development of a claims-based targeted healthcare safety monitoring system and application to three empirical examples.Drug safety · 2012
   Article
3. Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients.Drugs & aging · 2011
   Review
4. Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study.PloS one · 2011
   Article
5. Antidepressant-warfarin interaction and associated gastrointestinal bleeding risk in a case-control study.PloS one · 2011
   Article
6. [SSRI - treatment and bleeding. What risks do we take?].Der Nervenarzt · 2010
   Review
7. Ex-drinking may be a surrogate for unmeasured risk factors for upper gastrointestinal bleeding: reappraisal and an additional survey of subjects from a case-control study in Japan.European journal of epidemiology · 2009
   Article
8. Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study.Drug safety · 2008
   Article
9. Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study.BMJ (Clinical research ed.) · 2001
   Article

Corrections and comments

• Comment on
  Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study.1999

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as