ArticleLipids2000
Increased alpha-linolenic acid intake increases tissue alpha-linolenic acid content and apparent oxidation with little effect on tissue docosahexaenoic acid in the guinea pig.
Article in Lipids, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- Biosynthesis of long-chain omega-3 fatty acids by the nestlings of a generalist seabird.The Journal of experimental biology · 2025Article
- Comparing Soy and Milk Protein Regulation of Hepatic Omega-3 Fatty Acid Biosynthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice.International journal of molecular sciences · 2023Article
- Demonstrating a link between diet, gut microbiota and brain:Frontiers in nutrition · 2023Article
- Review
- Tissue-Specific Content of Polyunsaturated Fatty Acids in (n-3) Deficiency State of Rats.Foods (Basel, Switzerland) · 2022Article
- Enhanced omega-3 index after long- versus short-chain omega-3 fatty acid supplementation in dogs.Veterinary medicine and science · 2021Article
- Dietary supplementation of α-linolenic acid induced conversion of n-3 LCPUFAs and reduced prostate cancer growth in a mouse model.Lipids in health and disease · 2017Article
- Article
- Effects of diets high in unsaturated Fatty acids on socially induced stress responses in Guinea pigs.PloS one · 2014Article
- Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2.Journal of lipid research · 2013Article
- Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation.Dermatology research and practice · 2013Article
- Polyunsaturated fatty acid metabolism in prostate cancer.Cancer metastasis reviews · 2011Review
- Article
- A low alpha-linolenic intake during early life increases adiposity in the adult guinea pig.Nutrition & metabolism · 2010Article
- The relationship of diet and acne: A review.Dermato-endocrinology · 2009Article
- Epidermal surface lipids.Dermato-endocrinology · 2009Article
- Article
- Significance of coprophagy for the fatty acid profile in body tissues of rabbits fed different diets.Lipids · 2008Article
- Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.Lipids · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential fatty acids do not have identical roles in nutrition. Linoleic acid (LA) accumulates throughout the body of most mammals, whereas alpha-linolenic acid (ALA) is rarely found in tissue lipids to the same extent as LA. It has been argued that this is the result of metabolism of ALA to docosahexaenoic acid (DHA) or that ALA is rapidly beta-oxidized to acetyl CoA and CO2. In this study, we consider the effect of high and low ALA levels on the tissue distribution of ALA and other n-3 polyunsaturated fatty acids (PUFA) in all tissues. Guinea pigs were fed one of two defined diets for 3 wk from weaning with both diets containing 1.8% (by weight) of LA and either 1.7% ALA or 0.03% ALA. The high ALA diet was associated with significantly increased ALA levels in all tissues except the brain and significantly increased levels of long-chain n-3 PUFA in all tissues except intestines, brain, carcass, and skin. The long-chain n-3 PUFA content of the whole body was less than 5% of that of the ALA content in both diet groups, and the major long-chain n-3 PUFA (>66% of total) in the body was 22:5n-3. The brain was the only tissue where the DHA content exceeded that of 22:5n-3. On the low ALA diet, there appeared to be conservation of ALA based on a comparison of the ratio of LA to ALA in the tissues compared with that in the diet. On the high ALA diet there was a loss of ALA relative to LA in the tissues compared with the diet. These studies suggest that the low levels of tissue ALA in the guinea pig are likely the result of beta-oxidation or excretion via the skin and fur rather than metabolism to DHA.
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