ArticleThe EMBO journal2000
Two histone fold proteins, CHRAC-14 and CHRAC-16, are developmentally regulated subunits of chromatin accessibility complex (CHRAC).
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication-coupled histone incorporation.Science advances · 2025Article
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- Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes.Nature communications · 2021Article
- IMITATION SWITCH is required for normal chromatin structure and gene repression in PRC2 target domains.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Kinetochore-independent mechanisms of sister chromosome separation.PLoS genetics · 2021Article
- Loss of nucleosome remodelers CHRAC/ACF does not sensitize earlymicroPublication biology · 2020Article
- A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling.Nucleic acids research · 2019Article
- CHRAC/ACF contribute to the repressive ground state of chromatin.Life science alliance · 2018Article
- Review
- A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis.Developmental biology · 2016Article
- ISWI chromatin remodeling: one primary actor or a coordinated effort?Current opinion in structural biology · 2014Review
- Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.PLoS genetics · 2013Article
- Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2.Molecular cell · 2009Article
- Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI.PLoS genetics · 2008Article
- DNA polymerase epsilon: a polymerase of unusual size (and complexity).Progress in nucleic acid research and molecular biology · 2008Review
- Mechanisms of ATP dependent chromatin remodeling.Mutation research · 2007Review
- ATP-dependent chromatin remodeling complexes in Drosophila.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.Molecular and cellular biology · 2005Article
- Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo.Molecular and cellular biology · 2004Article
- Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo.Genes & development · 2004Article
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ISWI ATPase of Drosophila is a molecular engine that can drive a range of nucleosome remodelling reactions in vitro. ISWI is important for cell viability, developmental gene expression and chromosome structure. It interacts with other proteins to form several distinct nucleosome remodelling machines. The chromatin accessibility complex (CHRAC) is a biochemical entity containing ISWI in association with several other proteins. Here we report on the identification of the two smallest CHRAC subunits, CHRAC-14 and CHRAC-16. They contain histone fold domains most closely related to those found in sequence-specific transcription factors NF-YB and NF-YC, respectively. CHRAC-14 and CHRAC-16 interact directly with each other as well as with ISWI, and are associated with functionally active CHRAC. The developmental expression profiles of both subunits suggest specialized roles in chromatin remodelling reactions in the early embryo for both histone fold subunits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.