ArticleThe Journal of physiology2000
Adenosine A1 receptors modulate high voltage-activated Ca2+ currents and motor pattern generation in the xenopus embryo.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits.Frontiers in cellular neuroscience · 2020Article
- Modulation of spinal motor networks by astrocyte-derived adenosine is dependent on DJournal of neurophysiology · 2018Article
- AMolecular neurobiology · 2017Review
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
- Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism.Neurotoxicity research · 2015Article
- Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.Purinergic signalling · 2015Article
- Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus.Purinergic signalling · 2015Article
- Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.PloS one · 2015Article
- Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.Frontiers in neural circuits · 2014Article
- Purines as potential morphogens during embryonic development.Purinergic signalling · 2012Review
- Glial-derived adenosine modulates spinal motor networks in mice.Journal of neurophysiology · 2012Article
- Positive feedback loops sustain repeating bursts in neuronal circuits.Journal of biological physics · 2011Article
- Purinergic signaling in embryonic and stem cell development.Cellular and molecular life sciences : CMLS · 2011Review
- Release of adenosine and ATP during ischemia and epilepsy.Current neuropharmacology · 2009Article
- Activity-dependent release of adenosine: a critical re-evaluation of mechanism.Current neuropharmacology · 2008Article
- Altering cAMP levels within a central pattern generator modifies or disrupts rhythmic motor output.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: the lamprey hemicord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine causes voltage- and non-voltage-dependent inhibition of high voltage-activated (HVA) Ca2+ currents in Xenopus laevis embryo spinal neurons. As this inhibition can be blocked by 8-cyclopentyl-1, 3-dipropylxanthine (DPCPX) and mimicked by N6-cyclopentyladenosine (CPA) it appears to be mediated by A1 receptors. Agents active at A2 receptors either were without effect or could be blocked by DPCPX. AMP had no agonist action on these receptors. By using omega-conotoxin GVIA we found that adenosine inhibited an N-type Ca2+ current as well as a further unidentified HVA current that was insensitive to dihydropyridines, omega-agatoxin TK and omega-conotoxin MVIIC. Both types of current were subject to voltage- and non-voltage-dependent inhibition. We used CPA and DPCPX to test whether A1 receptors regulated spinal motor pattern generation in spinalized Xenopus embryos. DPCPX caused a near doubling of, while CPA greatly shortened, the length of swimming episodes. In addition, DPCPX slowed, while CPA greatly speeded up, the rate of run-down of motor activity. Our results demonstrate a novel action of A1 receptors in modulating spinal motor activity. Furthermore they confirm that adenosine is produced continually throughout swimming episodes and acts to cause the eventual termination of activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.