ArticleThe Journal of physiology2000
Distribution and activation of voltage-gated potassium channels in cell-attached and outside-out patches from large layer 5 cortical pyramidal neurons of the rat.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed, 180 citations in OpenAlex.
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- Dendritic Excitability and Synaptic Plasticity In Vitro and In Vivo.Neuroscience · 2022Review
- Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level.Journal of computational neuroscience · 2022Article
- Computational Concepts for Reconstructing and Simulating Brain Tissue.Advances in experimental medicine and biology · 2022Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- A-type KNeuropharmacology · 2018Article
- Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Journal of neurophysiology · 2018Article
- Potassium channels contribute to activity-dependent regulation of dendritic inhibition.Physiological reports · 2018Article
- Linearization of excitatory synaptic integration at no extra cost.Journal of computational neuroscience · 2018Article
- The stochastic nature of action potential backpropagation in apical tuft dendrites.Journal of neurophysiology · 2017Article
- Chronic CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Is realistic neuronal modeling realistic?Journal of neurophysiology · 2016Review
- Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing.Cell reports · 2015Article
- Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron.Frontiers in cellular neuroscience · 2015Review
- Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.Genes, brain, and behavior · 2014Article
- Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Translational stroke research · 2014Review
22 more citing papers are in PubMed but not listed here.
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated potassium channels were studied in cell-attached and outside-out patches from the soma and primary apical dendrite of large layer 5 pyramidal neurons in acute slices of rat sensorimotor cortex (22-25 degrees C). Ensemble averages revealed that some patches contained only fast, I(A)-like channels, other contained only I(K)-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. I(A) and I(K) channels had mean unitary conductances of 8.5 and 20.3 pS, respectively, and had distinctive patterns of gating. Peak activation curves for ensemble-averaged currents were described by the Boltzmann equation with half-maximal voltage [V(1/2)] and slope factor (k) values of -24.5 mV and 16.9 mV for I(A) and -7.6 mV and 10.1 mV for I(K) (patches < 250 microm from the soma) or -22.9 mV and 16.2 mV for I(A) (patches > 250 microm from the soma). The steady-state inactivation curve for I(A) gave V(1/2) and k values of -72.3 mV and -5.9 mV (< 250 microm from the soma) or -83.1 mV and -6.5 mV (> 250 microm from the soma). These values were similar to the corresponding data for I(A) and I(K) in nucleated patches from the same cell. The amount of I(A) and I(K) present in patches depended weakly on distance along the primary apical dendrite from the soma. The amplitude of I(A) increased, on the average, by 2.3 pA per 100 microm, while the amplitude of I(K) decreased by 0.4 pA per 100 microm. I(A) and I(K) channels in dendritic cell-attached patches were activated by the passage of a back-propagating action potential past the tip of the patch electrode. These results show directly that these potassium channels participate in action potential repolarisation, and thus contribute to the process of synaptic integration in these neurons.
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