ArticleThe Journal of physiology2000
Properties of voltage-gated potassium currents in nucleated patches from large layer 5 cortical pyramidal neurons of the rat.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 147 citations in OpenAlex.
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- Genistein Inhibits AβCellular and molecular neurobiology · 2019Article
- Transient Potassium Channels: Therapeutic Targets for Brain Disorders.Frontiers in cellular neuroscience · 2019Review
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- A-type KNeuropharmacology · 2018Article
- Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Journal of neurophysiology · 2018Article
- Increased transient NaThe Journal of physiology · 2017Article
- Gain Modulation of Cholinergic Neurons in the Medial Septum-Diagonal Band of Broca Through Hyperpolarization.Hippocampus · 2016Article
- Is realistic neuronal modeling realistic?Journal of neurophysiology · 2016Review
- A unified model for two modes of bursting in GnRH neurons.Journal of computational neuroscience · 2016Article
- Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex.Journal of neurophysiology · 2016Article
- Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron.Frontiers in cellular neuroscience · 2015Review
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Abstract
Voltage-gated potassium currents were studied in nucleated outside-out patches obtained from large layer 5 pyramidal neurons in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats (22-25 C). Two main types of current were found, an A-current (IA) and a delayed rectifier current (IK), which were blocked by 4-aminopyridine (5 mM) and tetraethylammonium (30 mM), respectively. Recovery from inactivation was mono-exponential (for IA) or bi-exponential (for IK) and strongly voltage dependent. Both IA and IK could be almost fully inactivated by depolarising prepulses of sufficient duration. Steady-state inactivation curves were well fitted by the Boltzmann equation with half-maximal voltage (V ) and slope factor (k) values of -81.6 mV and -6.7 mV for IA, and -66.6 mV and -9.2 mV for IK. Peak activation curves were described by the Boltzmann equation with V and k values of -18.8 mV and 16.6 mV for IA, and -9.6 mV and 13.2 mV for IK. IA inactivated mono-exponentially during a depolarising test pulse, with a time constant ( approximately 7 ms) that was weakly dependent on membrane potential. IK inactivated bi-exponentially with time constants ( approximately 460 ms, approximately 4.2 s) that were also weakly voltage dependent. The time to peak of both IA and IK depended strongly on membrane potential. The kinetics of IA and IK were described by a Hodgkin-Huxley-style equation of the form mNh, where N was 3 for IA and 1 for IK. These results provide a basis for understanding the role of voltage-gated potassium currents in the firing properties of large layer 5 pyramidal neurons of the rat neocortex.
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