ArticleEnvironmental health perspectives2000
Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes.
Article in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis.Pediatric radiology · 2021Pooled it
- Are pre- or postnatal diagnostic X-rays a risk factor for childhood cancer? A systematic review.Radiation and environmental biophysics · 2008Pooled it
- Cancer risks following diagnostic and therapeutic radiation exposure in children.Pediatric radiology · 2006Pooled it
- Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE).Haematologica · 2018Trial
- Worldwide variations in the knowledge and use of fluoroscopy during percutaneous nephrolithotomy-should we do better? A survey by the European Association of Urology Section for Uro-Technology and the International Alliance of Urolithiasis.Asian journal of urology · 2025Article
- Low-Value Diagnostic Imaging in Children with Medicaid.The Journal of pediatrics · 2021Article
- Irradiation level related to intraoperative imaging device in paediatric elastic stable intramedullary nailing: preliminary prospective study on 51 patients using PCXMC software.Journal of children's orthopaedics · 2020Article
- Monitoring of a hip surveillance programme protects infants from radiation and surgical intervention.The bone & joint journal · 2020Observational
- Cranial Suture Measurement by 2-point Method in Ultrasound Screening of Craniosynostosis.Plastic and reconstructive surgery. Global open · 2019Article
- Intraoperative 2D C-arm and 3D O-arm in children: a comparative phantom study.Journal of children's orthopaedics · 2018Article
- The contribution ofCancer management and research · 2018Article
- Children's Cancer and Environmental Exposures: Professional Attitudes and Practices.Journal of pediatric hematology/oncology · 2015Article
- Genetic susceptibility in childhood acute leukaemias: a systematic review.Ecancermedicalscience · 2015Review
- The Childhood Leukemia International Consortium.Cancer epidemiology · 2013Article
- Risk of cancer associated with cardiac catheterization procedures during childhood: a cohort study in France.BMC public health · 2013Article
- Epigenetics in radiation biology: a new research frontier.Frontiers in genetics · 2013Article
- Factors associated with fluoroscopy exposure during pediatric catheter ablation utilizing electroanatomical mapping.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2012Article
- Cancer mortality among atomic bomb survivors exposed as children.Environmental health and preventive medicine · 2012Article
- Lung ultrasonography of pulmonary complications in preterm infants with respiratory distress syndrome.Upsala journal of medical sciences · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study was to measure risk of childhood acute lymphoblastic leukemia associated with reported postnatal diagnostic X rays and to determine if it was modified in the presence of variants in genes involved in DNA repair. We conducted a population-based case-control study with 491 cases and 491 healthy controls among children 0-9 years of age at diagnosis. To evaluate gene-environment interaction, we used a subgroup of 129 cases. The adjusted odds ratio (OR) for one reported postnatal child X ray versus none was 1.04 [95% confidence interval (CI), 0.72-1.49], whereas the OR for two or more X rays was 1.61 (CI, 1.13-2.28). Among girls, the former ORs were 1.14 (CI, 0.66-1.96) and 2.26 (1. 20-4.23), respectively. Among girls who carried the hMSH3 [exon (ex) 23] variant, the ORs were 3.33 (CI, 0.75-14.82) for one X ray and 0. 27 (CI, 0.05-1.57) for two or more X rays, whereas among those who carried the XRCCI (ex 6) variant, the ORs were 1.45 (0.11-19.08) and 6.66 (0.78-56.63), respectively. On the other hand, at low levels of exposure, boys seemed protected by the variant hMLH1 (ex 8). The latter results must be interpreted with caution but suggest that the effect of diagnostic X rays could be modified by variants in repair genes according to sex. Few studies have evaluated the risk of postnatal diagnostic irradiation, which was moderately strong here; we are not aware of any studies that also considered the effect of polymorphisms in DNA repair genes. Based on the present results, both aspects deserve further study.
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