ArticleGenome research2000
Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Molecular cloning and characterization of a novel mouse actin-binding protein Zfp185.Journal of molecular histology · 2008Article
- Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement.American journal of human genetics · 2007Article
- Validation of mRNA/EST-based gene predictions in human Xp11.4 revealed differences to the organization of the orthologous mouse locus.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Whole genome shotgun sequencing of Brassica oleracea and its application to gene discovery and annotation in Arabidopsis.Genome research · 2005Article
- Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.Genome research · 2004Article
- Biological functions of melanoma-associated antigens.World journal of gastroenterology · 2004Review
- Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region.Genome research · 2002Article
- Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression.The Biochemical journal · 2002Article
- Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine.Genome research · 2002Article
- Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.Genome research · 2002Article
- Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence.Genome research · 2001Article
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.Nucleic acids research · 2001Article
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.Genome research · 2001Article
- Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.Genome research · 2001Article
- What use is the human genome for understanding the mouse?Genome biology · 2001Article
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Authors and funding
31 authors.
Funding
Abstract
The progress of human and mouse genome sequencing programs presages the possibility of systematic cross-species comparison of the two genomes as a powerful tool for gene and regulatory element identification. As the opportunities to perform comparative sequence analysis emerge, it is important to develop parameters for such analyses and to examine the outcomes of cross-species comparison. Our analysis used gene prediction and a database search of 430 kb of genomic sequence covering the Bpa/Str region of the mouse X chromosome, and 745 kb of genomic sequence from the homologous human X chromosome region. We identified 11 genes in mouse and 13 genes and two pseudogenes in human. In addition, we compared the mouse and human sequences using pairwise alignment and searches for evolutionary conserved regions (ECRs) exceeding a defined threshold of sequence identity. This approach aided the identification of at least four further putative conserved genes in the region. Comparative sequencing revealed that this region is a mosaic in evolutionary terms, with considerably more rearrangement between the two species than realized previously from comparative mapping studies. Surprisingly, this region showed an extremely high LINE and low SINE content, low G+C content, and yet a relatively high gene density, in contrast to the low gene density usually associated with such regions.
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