ArticleThe American journal of pathology2000
Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 111 citations in OpenAlex.
- 'Two-faces' of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment.Discover oncology · 2023Review
- High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells.Biomolecules & therapeutics · 2022Article
- Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine.Nanomaterials (Basel, Switzerland) · 2021Review
- Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells.Matrix biology plus · 2019Article
- Thymosin α1 Interacts with Hyaluronic Acid Electrostatically by Its Terminal Sequence LKEKK.Molecules (Basel, Switzerland) · 2017Article
- A Trickster in Disguise: Hyaluronan's Ambivalent Roles in the Matrix.Frontiers in oncology · 2017Review
- NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling.Oncotarget · 2016Article
- Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.Frontiers in immunology · 2015Review
- Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment.Cancer research · 2013Article
- Role of CD44 as a marker of cancer stem cells in head and neck cancer.Biologics : targets & therapy · 2012Article
- Article
- Soluble CD44 interacts with intermediate filament protein vimentin on endothelial cell surface.PloS one · 2011Article
- Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms.Cell and tissue research · 2010Review
- Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Protumorigenic role of HAPLN1 and its IgV domain in malignant pleural mesothelioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells.Seminars in cancer biology · 2008Review
- Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2008Review
- In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.The American journal of pathology · 2007Article
- Hyaluronan oligosaccharides inhibit tumorigenicity of osteosarcoma cell lines MG-63 and LM-8 in vitro and in vivo via perturbation of hyaluronan-rich pericellular matrix of the cells.The American journal of pathology · 2007Article
- Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.Experimental cell research · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hyaluronan accumulates in ascites during intraperitoneal proliferation of TA3/St murine mammary carcinoma cells and at sites of their invasion of the peritoneal wall. To determine whether hyaluronan is functionally involved in these events, ascites tumor formation was compared in mice injected intraperitoneally with stable transfectants of TA3/St cells that overexpress soluble CD44, a hyaluronan-binding protein, versus in mice injected with transfectants expressing mutated soluble CD44 that does not bind hyaluronan. The soluble CD44 transfectants temporarily grew at a reduced rate within the peritoneal cavity, then went into G(1) arrest and were subsequently cleared from the peritoneum. However, transfectants overexpressing mutant soluble CD44 that does not bind hyaluronan exhibited similar ascites accumulation, growth rates, and cell-cycle profiles in vivo to wild-type and vector-transfected TA3/St cells, all of which continued to grow until the tumors became fatal. The soluble CD44-transfected TA3/St cells also failed to attach to and form tumors in the peritoneal wall. When grown in vitro in soft agar, the soluble CD44 transfectants exhibited a dramatic reduction in colony formation compared to wild-type, vector-transfected, and mutant soluble CD44-transfected TA3/St cells. Thus, perturbation of hyaluronan interactions by soluble CD44 has a direct effect on the growth characteristics of these tumor cells, leading to inhibition of anchorage-independent growth in vitro and ascites growth in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.