ArticleThe American journal of pathology2000
Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Environmental impact on carcinogenesis under BRCA1 haploinsufficiency.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Review
- Iron as spirit of life to share under monopoly.Journal of clinical biochemistry and nutrition · 2022Article
- Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.Cancers · 2020Review
- Systemic redox status in lung cancer patients is related to altered glucose metabolism.PloS one · 2018Article
- Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells.American journal of physiology. Renal physiology · 2017Article
- Insulin-like growth factor-1 signaling in renal cell carcinoma.BMC cancer · 2016Review
- Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.Redox biology · 2015Article
- Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs.International journal of biological sciences · 2015Article
- Article
- Iron and thiols as two major players in carcinogenesis: friends or foes?Frontiers in pharmacology · 2014Review
- 8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome.Oncology letters · 2012Article
- The Nucleolus Takes Control of Protein Trafficking Under Cellular Stress.Molecular and cellular pharmacology · 2010Article
- The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.Toxicological sciences : an official journal of the Society of Toxicology · 2008Article
- Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.Cancer letters · 2007Review
- Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.Nucleic acids research · 2006Article
- Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis.Oncogene · 2004Article
- A novel mechanism of repression of the vascular endothelial growth factor promoter, by single strand DNA binding cold shock domain (Y-box) proteins in normoxic fibroblasts.Nucleic acids research · 2002Article
- Gene expression in Peyronie's disease.International journal of impotence research · 2002Review
- Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers.The American journal of pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferric nitrilotriacetate induces oxidative damage in renal proximal tubules that ultimately leads to a high incidence of renal cell carcinoma (RCC) in rats. In search of genes specifically involved in oxystress-induced carcinogenesis, we have applied a modified fluorescent differential display technique to the tumors and an established cell line as well as their non-neoplastic counterparts. We screened approximately 84,000 products. Reverse Northern blotting confirmed differential expression of 20 transcripts, which showed either significant increase, decrease or lack of expression in the RCCs. Five cDNA clones encoded novel products of unknown function. Fifteen cDNA clones were identified by homology search, which included annexin II, Y-box binding protein, ribosomal proteins, heat shock proteins, DNA polymerase, nonmuscle caldesmon (increased); protein tyrosine phosphatase (decreased); selenoprotein P, stromal cell-derived factor 1, intestinal trefoil protein, nicotinamide adenine dinucleotide, reduced form (NADH) dehydrogenase, and insulin-like growth factor binding protein 7 (deleted). Most of the identified genes were associated with stress-response or cellular proliferation. These results suggest that multiple, interactive genetic pathways are involved in carcinogenesis induced by oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.