ArticleJournal of molecular neuroscience : MN
Synaptogenesis and myopathy under acetylcholinesterase overexpression.
Article in Journal of molecular neuroscience : MN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Reference intervals for B-esterases in gull, Larus michahellis (Nauman, 1840) from Northwest Spain: influence of age, gender, and tissue.Environmental science and pollution research international · 2018Article
- Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function.International journal of molecular sciences · 2016Review
- Characterization of placental cholinesterases and activity induction associated to environmental organophosphate exposure.Toxicology reports · 2015Article
- An adult patient with ocular myasthenia and unusually long spontaneous remission.Case reports in neurological medicine · 2014Article
- New treatments for myasthenia: a focus on antisense oligonucleotides.Drug design, development and therapy · 2013Review
- Acetylcholinesterase inhibitors and Gulf War illnesses.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Acetylcholinesterase readthrough peptide shares sequence similarity to the 28-53 peptide sequence of the acetylcholinesterase adhesion-mediating site and competes for ligand binding in vitro.Journal of molecular neuroscience : MN · 2007Article
- ARP, the cleavable C-terminal peptide of "readthrough" acetylcholinesterase, promotes neuronal development and plasticity.Journal of molecular neuroscience : MN · 2006Review
- Postnatal development of the basolateral complex of rabbit amygdala: a stereological and histochemical study.Journal of anatomy · 2003Article
- Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental, congenital, and acquired immunological insults perturbing neuromuscular junction (NMJ) activity may induce a variety of debilitating neuromuscular pathologies. However, the molecular elements linking NMJ dysfunction to long-term myopathies are unknown. Here, we report dramatically elevated levels of mRNA encoding c-Fos and the "readthrough" (R) variant of acetylcholinesterase (AChE) in muscles of transgenic mice overexpressing synaptic (S) AChE in motoneurons and in control mice treated with the irreversible cholinesterase inhibitor diisopropylfluorophosphonate (DFP). Tongue muscles from DFP-treated and AChE-S transgenic mice displayed exaggerated neurite branching and disorganized, wasting fibers. Moreover, diaphragm muscles from both transgenic and DFP-treated mice exhibited NMJ proliferation. 2'-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA suppressed feedback upregulation of AChE and ameliorated DFP-induced NMJ proliferation. Our findings demonstrate common transcriptional responses to cholinergic NMJ stress of diverse origin, and implicate deregulated AChE expression in excessive neurite outgrowth, uncontrolled synaptogenesis, and myopathology.
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