ArticleProceedings of the National Academy of Sciences of the United States of America2000
Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Chemical Decorations of "MARs" Residents in Orchestrating Eukaryotic Gene Regulation.Frontiers in cell and developmental biology · 2020Review
- Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.Internal medicine review (Washington, D.C. : Online) · 2017Article
- CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling.Oncogene · 2015Article
- Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.Frontiers in genetics · 2014Article
- A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogaster and vertebrates.Molecular and cellular biology · 2011Article
- Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.Human molecular genetics · 2010Article
- Article
- Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family.Genes, chromosomes & cancer · 2010Article
- p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.The Journal of biological chemistry · 2009Article
- Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function.Infection and immunity · 2008Article
- CCAAT displacement protein regulates nuclear factor-kappa beta-mediated chemokine transcription in melanoma cells.Melanoma research · 2007Article
- Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression.Molecular and cellular biology · 2006Article
- Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Molecular and cellular biology · 2006Article
- CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation.Journal of molecular medicine (Berlin, Germany) · 2003Review
- Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.The EMBO journal · 2002Article
- Nf-kappa B, chemokine gene transcription and tumour growth.Nature reviews. Immunology · 2002Review
- Role of CXCL1 in tumorigenesis of melanoma.Journal of leukocyte biology · 2002Review
- Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility.Molecular and cellular biology · 2002Article
- CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcription.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CCAAT displacement protein/cut homologue (CDP/cut) is a divergent homeodomain protein that is highly conserved through evolution and has properties of a potent transcriptional repressor. CDP/cut contains three conserved cut-repeat domains and a conserved homeobox, each involved in directing binding specificity to unique nucleotide sequence elements. Furthermore, CDP/cut may play a role as a structural component of chromatin through its direct interaction with nucleosomal DNA and association with nuclear matrix attachment regions. CDP/cut is cell-cycle regulated through interactions with Rb, p107, specific kinases and phosphatases directing the transcriptional activity of CDP/cut on such genes encoding p21(WAF1,CIP1), c-myc, thymidine kinase, and histones. Our previous studies indicate that CDP/cut is associated with histone deacetylase activity and is associated with a corepressor complex through interactions with histone deacetylases. Here, we report the interaction of CDP/cut with CBP and p300/CREB-binding protein-associated factor (PCAF) along with the modification of CDP/cut by the histone acetyltransferase PCAF. Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function. These observations are consistent with the ability of CDP/cut to regulate genes as a transcriptional repressor, suggesting acetylation as a mechanism that regulates CDP/cut function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.