ArticleProceedings of the National Academy of Sciences of the United States of America2000
A role of transcriptional activators as antirepressors for the autoinhibitory activity of TATA box binding of transcription factor IID.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Multiple direct interactions of TBP with the MYC oncoprotein.Nature structural & molecular biology · 2019Article
- High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.Nature structural & molecular biology · 2013Article
- The transcriptional repressor activator protein Rap1p is a direct regulator of TATA-binding protein.The Journal of biological chemistry · 2008Article
- Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II.Nucleic acids research · 2008Article
- SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment.The EMBO journal · 2006Article
- Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation.Molecular and cellular biology · 2004Article
- Mapping key functional sites within yeast TFIID.The EMBO journal · 2004Article
- The transcriptional activator GAL4-VP16 regulates the intra-molecular interactions of the TATA-binding protein.Journal of biosciences · 2003Article
- Structural and functional analysis of mutations along the crystallographic dimer interface of the yeast TATA binding protein.Molecular and cellular biology · 2003Article
- Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP).Nucleic acids research · 2003Article
- The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions.Molecular and cellular biology · 2002Article
- TAF(II)170 interacts with the concave surface of TATA-binding protein to inhibit its DNA binding activity.Molecular and cellular biology · 2001Article
- Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors.Molecular and cellular biology · 2001Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we propose a mechanism of transcriptional activation that involves antirepression of this autoinhibitory activity by transcriptional activators. Like the autoinhibitory domain of TFIID, various acidic activators interact with the TATA box-binding domain of TBP. Moreover, the autoinhibitory domain of TFIID, which is known to interact with only the TATA box-binding domain of TBP, acts as an activation domain when fused to the GAL4 DNA-binding domain, indicating that interaction with the TATA-binding domain of TBP is crucial for activation of transcription. In a reciprocal fashion, the acidic activation domains can function as the autoinhibitory domain when the latter is replaced by the former within TFIID. These results indicate that activation domains and the autoinhibitory domain of TFIID are interchangeable, supporting a role for transcriptional activators as antirepressors of the autoinhibitory activity of the TATA box binding of TFIID.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.