ReviewEnvironmental health perspectives2000
Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.
Review in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing.Environment international · 2023Pooled it
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- A gestational vulnerability window for smoking exposure and the increased risk of preterm birth: how timing and intensity of maternal smoking matter.Reproductive health · 2019Article
- Windows of sensitivity to toxic chemicals in the development of reproductive effects: an analysis of ATSDR's toxicological profile database.International journal of environmental health research · 2018Article
- Environmental Chemicals in Breast Milk and Formula: Exposure and Risk Assessment Implications.Environmental health perspectives · 2018Review
- Scientific opinion on pesticides in foods for infants and young children.EFSA journal. European Food Safety Authority · 2018Article
- Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?Women's midlife health · 2018Article
- Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age.EFSA journal. European Food Safety Authority · 2017Article
- A Review of the Field on Children's Exposure to Environmental Contaminants: A Risk Assessment Approach.International journal of environmental research and public health · 2017Review
- Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys.Environmental health perspectives · 2015Article
- Translational toxicology: a developmental focus for integrated research strategies.BMC pharmacology & toxicology · 2013Article
- Windows of lead exposure sensitivity, attained height, and body mass index at 48 months.The Journal of pediatrics · 2012Article
- A framework for assessing risks to children from exposure to environmental agents.Environmental health perspectives · 2004Review
- An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population.Environmental health perspectives · 2001Article
- Identifying critical windows of exposure for children's health.Environmental health perspectives · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurring prenatally and further maturational events occurring in the perinatal period and at puberty. Complex endocrine signals as well as other regulatory factors (genetics, growth factors) are involved at all stages. Evidence from animal models and human studies indicates that many specific events can be perturbed by a variety of toxicants, with endocrine-mediated mechanisms being the more widely studied. Prioritized research needs include basic studies on the cellular-molecular and endocrine regulation of sexual differentiation and development; increased efforts regarding potential adverse effects on development in females, including breast development; expanded animal studies on different classes of chemicals, comparing responses during development (prenatal and postnatal) with responses in adults; and, more extensive explorations regarding the reproductive biology and toxicology of puberty in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.