ReviewImmunologic research2000
Role of BMK1 in regulation of growth factor-induced cellular responses.
Review in Immunologic research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma.International journal of molecular sciences · 2023Review
- The significance of ERK5 catalytic-independent functions in disease pathways.Frontiers in cell and developmental biology · 2023Review
- Review
- TheAIMS neuroscience · 2022Review
- Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation.Inflammopharmacology · 2021Review
- Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for….Biochemical Society transactions · 2020Review
- Functions of p38 MAP Kinases in the Central Nervous System.Frontiers in molecular neuroscience · 2020Review
- Microalgae as Potential Anti-Inflammatory Natural Product Against Human Inflammatory Skin Diseases.Frontiers in pharmacology · 2020Review
- Over-expression ofOncoTargets and therapy · 2018Article
- Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.BMC genomics · 2017Article
- ERK5 and Cell Proliferation: Nuclear Localization Is What Matters.Frontiers in cell and developmental biology · 2016Review
- Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.The American journal of pathology · 2014Article
- The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis.Journal of signal transduction · 2011Article
- MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.Journal of cell science · 2009Article
- Regulation of MAPKs by growth factors and receptor tyrosine kinases.Biochimica et biophysica acta · 2007Review
- The ERK cascade: a prototype of MAPK signaling.Molecular biotechnology · 2005Review
- Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.Molecular and cellular biology · 2005Article
- Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction.Molecular and cellular biology · 2003Article
- Activation of cyclin D1 expression by the ERK5 cascade.Oncogene · 2003Article
- Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.EMBO reports · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Big mitogen-activated protein kinase (MAPK) 1 (BMK1), also known as ERK5, is a recently identified member of the mammalian MAPK family. Cellular stimulation of BMK1 is induced in response to growth factors, oxidative stress, and hyperosmolar conditions. Specific members of the myocyte enhancer factor 2 family of transcription factors that regulate growth factor-induced early gene expression have been identified as direct downstream targets of BMK1 activity. Recent studies have shown that growth factors of the epidermal growth factor family mediate the sequential activation of a kinase cascade consisting of MAPK kinase kinase 3, MAPK kinase 5, and BMK1. Most importantly, the activation of this signal transduction pathway has been shown to be required for growth factor-mediated cell proliferation and cell-cycle progression. Collectively, these studies establish BMK1 as an important regulator of growth factor-induced cellular responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.