ReviewImmunologic research2000
Rho GTPase signaling in inflammation and transformation.
Review in Immunologic research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.PLoS genetics · 2014Pooled it
- Article
- Microglial polarization: novel therapeutic mechanism against Alzheimer's disease.Inflammopharmacology · 2020Review
- Bilobol inhibits the lipopolysaccharide-induced expression and distribution of RhoA in HepG2 human hepatocellular carcinoma cells.Oncology letters · 2015Article
- Rho/ROCK signaling in motility and metastasis of gastric cancer.World journal of gastroenterology · 2014Review
- LPS-induced nuclear translocation of RhoA is dependent on NF-κB in the human lung cancer cell line A549.Oncology letters · 2012Article
- Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking.Annals of human genetics · 2009Article
- Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.American journal of human genetics · 2007Article
- Scambio, a novel guanine nucleotide exchange factor for Rho.Molecular cancer · 2004Article
- Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells.Infection and immunity · 2003Article
- Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular Rho GTPases provide an important regulatory mechanism to connect cell-surface-generated signals with the nucleus. By cycling between the active (guanosine 5'-triphosphate [GTP]) and inactive (guanosine 5'-diphosphate) state, these GTP-binding proteins control cellular functions ranging from dynamic actin remodeling and activation of transcription factors to cell-cycle progression and cellular transformation. Their contribution to these very diverse processes makes them an essential part of cell movement, growth, and apoptosis. Upstream regulatory mechanisms, as well as a variety of downstream effector molecules, enable Rho GTPases to act in a specific, orchestrated manner, dictating cellular responses. In this article, I review my laboratory's work centering on the goal of determining how specificity in intracellular signaling is achieved and identifying molecular mechanisms of Rho GTPase-mediated processes in innate immune and transformed cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.