ArticleOncogene2000
Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Construction of a TP53 mutation-associated ceRNA network as prognostic biomarkers in hepatocellular carcinoma.Heliyon · 2024Article
- Expression and clinical significance of lncRNA TCL6 in serum of patients with preeclampsia.Experimental and therapeutic medicine · 2022Article
- An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells.Journal of experimental & clinical cancer research : CR · 2021Review
- Article
- A Panel of Four-lncRNA Signature as a Potential Biomarker for Predicting Survival in Clear Cell Renal Cell Carcinoma.Journal of Cancer · 2020Article
- Lnc-TCL6 is a potential biomarker for early diagnosis and grade in liver-cirrhosis patients.Gastroenterology report · 2019Article
- Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.Blood cancer journal · 2019Article
- Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.Journal of hematology & oncology · 2019Article
- Identification of Six Potentially Long Noncoding RNAs as Biomarkers Involved Competitive Endogenous RNA in Clear Cell Renal Cell Carcinoma.BioMed research international · 2018Article
- Review
- Analysis of long non-coding RNA expression profiles in clear cell renal cell carcinoma.Oncology letters · 2017Article
- Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma.Oncotarget · 2017Article
- A Decision Tree Based Classifier to Analyze Human Ovarian Cancer cDNA Microarray Datasets.Journal of medical systems · 2016Article
- Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort.PloS one · 2014Article
- Long non-coding RNAs in haematological malignancies.International journal of molecular sciences · 2013Review
- Reduced level of the BCL11B protein is associated with adult T-cell leukemia/lymphoma.PloS one · 2013Article
- TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients.International journal of hematology · 2012Article
- Article
- TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia.Journal of human genetics · 2006Article
- 3' rapid amplification of cDNA ends (RACE) walking for rapid structural analysis of large transcripts.Journal of human genetics · 2004Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A region on chromosome 14q32.1 is often involved in chromosomal translocations and inversions with one of the T-cell receptor loci in T-cell lymphoproliferative diseases. The breakpoints of the different rearrangements segregate into two clusters; a cluster due to inversion on the centromeric side and a cluster due to simple balanced translocations on the telomeric side. If the target gene activated by these different types of chromosomal rearrangements is the same, the gene must be localized between the two clusters of breakpoints in a region of around 160 kb. Within this breakpoint cluster region, we isolated two genes; namely, TCL1 and TML1/TCL1b genes. In the course of characterizing the TML1 gene, we further identified a third novel gene, which we named TCL6 (T-cell leukemia/lymphoma 6), from a region 7 kb upstream of the TML1 locus. The TCL6 gene expressed at least 11 isoforms through very complex alternative-splicing, including splicing with the TML1 gene. Those isoforms encode at least five open reading frames (ORFs) with no homology to known sequences. The localization of the proteins corresponding to these ORF was determined by fusing green fluorescence protein at the carboxyl terminal of each ORF. ORF141 and ORF72 were observed in the cytoplasmic region, while ORF105, ORF119, and ORF163 were predominantly localized in the nuclear region. Since the TCL6 gene was expressed in T-cell leukemia carrying a t(14;14)(q11;q32.1) chromosome translocation and was not expressed in normal T-cells (just like the TML1 and TCL1 genes), it is also a candidate gene potentially involved in leukemogenesis. Oncogene (2000).
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