ArticleThe Journal of cell biology2000
The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 120 citations in OpenAlex.
- Anoikis resistance--protagonists of breast cancer cells survive and metastasize after ECM detachment.Cell communication and signaling : CCS · 2023Review
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- Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk.World journal of biological chemistry · 2016Review
- NG2 Proteoglycan-Dependent Contributions of Pericytes and Macrophages to Brain Tumor Vascularization and Progression.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Article
- NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization.Oncoimmunology · 2015Article
- Cadherin-based transsynaptic networks in establishing and modifying neural connectivity.Current topics in developmental biology · 2015Review
- Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder.Genome biology · 2014Article
- FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance.Oncogene · 2013Article
- N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.Nature communications · 2013Article
- Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions.Frontiers in molecular neuroscience · 2013Article
- Integrins as receptor targets for neurological disorders.Pharmacology & therapeutics · 2012Review
- Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?Journal of signal transduction · 2012Article
- Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning.PloS one · 2012Article
- Integrins and cadherins join forces to form adhesive networks.Journal of cell science · 2011Review
- Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype.Oncotarget · 2010Article
- Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling.Journal of cell science · 2010Article
- Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.The EMBO journal · 2008Article
- The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons.BMC developmental biology · 2007Article
- Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cadherins and integrins must function in a coordinated manner to effectively mediate the cellular interactions essential for development. We hypothesized that exchange of proteins associated with their cytoplasmic domains may play a role in coordinating function. To test this idea, we used Trojan peptides to introduce into cells and tissues peptide sequences designed to compete for the interaction of specific effectors with the cytoplasmic domain of N-cadherin, and assayed their effect on cadherin- and integrin-mediated adhesion and neurite outgrowth. We show that a peptide mimicking the juxtamembrane (JMP) region of the cytoplasmic domain of N-cadherin results in inhibition of N-cadherin and beta1-integrin function. The effect of JMP on beta1-integrin function depends on the expression of N-cadherin and is independent of transcription or translation. Treatment of cells with JMP results in the release of the nonreceptor tyrosine kinase Fer from the cadherin complex and its accumulation in the integrin complex. A peptide that mimics the first coiled-coil domain of Fer prevents Fer accumulation in the integrin complex and reverses the inhibitory effect of JMP. These findings suggest a new mechanism through which N-cadherin and beta1-integrins are coordinately regulated: loss of an effector from the cytoplasmic domain of N-cadherin and gain of that effector by the beta1-integrin complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.