ArticleThe Journal of cell biology2000
The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 100 citations in OpenAlex.
- Peroxisome Proliferator FpPEX11 Is Involved in the Development and Pathogenicity inInternational journal of molecular sciences · 2022Article
- Article
- Peroxisome biogenesis, membrane contact sites, and quality control.EMBO reports · 2019Review
- Article
- Distinct requirements for intra-ER sorting and budding of peroxisomal membrane proteins from the ER.The Journal of cell biology · 2016Article
- Article
- Article
- Emerging role of the endoplasmic reticulum in peroxisome biogenesis.Frontiers in physiology · 2013Review
- The role of the endoplasmic reticulum in peroxisome biogenesis.Cold Spring Harbor perspectives in biology · 2013Review
- Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Atg35, a micropexophagy-specific protein that regulates micropexophagic apparatus formation in Pichia pastoris.Autophagy · 2011Article
- Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.The Journal of biological chemistry · 2009Article
- Peroxisome matrix and membrane protein biogenesis.IUBMB life · 2009Review
- Targeting of hFis1 to peroxisomes is mediated by Pex19p.The Journal of biological chemistry · 2008Article
- Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes.Eukaryotic cell · 2007Article
- Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals.Molecular biology of the cell · 2004Article
- Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p.Molecular biology of the cell · 2004Article
- PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.The Journal of cell biology · 2004Article
- PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.The Journal of cell biology · 2004Article
- Peroxisome biogenesis occurs in an unsynchronized manner in close association with the endoplasmic reticulum in temperature-sensitive Yarrowia lipolytica Pex3p mutants.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pex19p is a protein required for the early stages of peroxisome biogenesis, but its precise function and site of action are unknown. We tested the interaction between Pex19p and all known Pichia pastoris Pex proteins by the yeast two-hybrid assay. Pex19p interacted with six of seven known integral peroxisomal membrane proteins (iPMPs), and these interactions were confirmed by coimmunoprecipitation. The interactions were not reduced upon inhibition of new protein synthesis, suggesting that they occur with preexisting, and not newly synthesized, pools of iPMPs. By mapping the domains in six iPMPs that interact with Pex19p and the iPMP sequences responsible for targeting to the peroxisome membrane (mPTSs), we found the majority of these sites do not overlap. Coimmunoprecipitation of Pex19p from fractions that contain peroxisomes or cytosol revealed that the interactions between predominantly cytosolic Pex19p and the iPMPs occur in the organelle pellet that contains peroxisomes. These data, taken together, suggest that Pex19p may have a chaperone-like role at the peroxisome membrane and that it is not the receptor for targeting of iPMPs to the peroxisome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.