ArticleMolecular biology of the cell2000
Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
- An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule.Function (Oxford, England) · 2022Article
- Membrane Heterogeneity Controls Cellular Endocytic Trafficking.Frontiers in cell and developmental biology · 2020Review
- A New Look at the Functional Organization of the Golgi Ribbon.Frontiers in cell and developmental biology · 2019Article
- Membrane Transport across Polarized Epithelia.Cold Spring Harbor perspectives in biology · 2017Review
- The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells.Nature communications · 2016Article
- Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- AP-1/σ1B-Dependent SV Protein Recycling Is Regulated in Early Endosomes and Is Coupled to AP-2 Endocytosis.Molecular neurobiology · 2015Article
- TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.Molecular biology of the cell · 2014Article
- Cargo sorting in the endocytic pathway: a key regulator of cell polarity and tissue dynamics.Cold Spring Harbor perspectives in biology · 2014Review
- Organization and execution of the epithelial polarity programme.Nature reviews. Molecular cell biology · 2014Review
- Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo.American journal of physiology. Cell physiology · 2014Article
- The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia.The EMBO journal · 2013Article
- Role of membrane traffic in the generation of epithelial cell asymmetry.Nature cell biology · 2012Review
- Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.Development (Cambridge, England) · 2012Article
- Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells.Experimental cell research · 2012Article
- The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation.PloS one · 2012Article
- The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.Journal of the National Cancer Institute · 2011Article
- Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.Molecular biology of the cell · 2011Article
- Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.Cytoskeleton (Hoboken, N.J.) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When fluid-phase markers are internalized from opposite poles of polarized Madin-Darby canine kidney cells, they accumulate in distinct apical and basolateral early endosomes before meeting in late endosomes. Recent evidence suggests that significant mixing of apically and basolaterally internalized membrane proteins occurs in specialized apical endosomal compartments, including the common recycling endosome and the apical recycling endosome (ARE). The relationship between these latter compartments and the fluid-labeled apical early endosome is unknown at present. We report that when the apical recycling marker, membrane-bound immunoglobulin A (a ligand for the polymeric immunoglobulin receptor), and fluid-phase dextran are cointernalized from the apical poles of Madin-Darby canine kidney cells, they enter a shared apical early endosome (</=2.5 min at 37 degrees C) and are then rapidly segregated from one another. The dextran remains in the large supranuclear EEA1-positive early endosomes while recycling polymeric immunoglobulin receptor-bound immunoglobulin A is delivered to a Rab11-positive subapical recycling compartment. This latter step requires an intact microtubule cytoskeleton. Receptor-bound transferrin, a marker of the basolateral recycling pathway, has limited access to the fluid-rich apical early endosome but is excluded from the subapical elements of the Rab11-positive recycling compartment. We propose that the term ARE be used to describe the subapical Rab11-positive compartment and that the ARE is distinct from both the transferrin-rich common recycling endosome and the fluid-rich apical early endosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.