ArticleMolecular and cellular biology2000
Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 123 citations in OpenAlex.
- Leydig Cell-Specific DAX1-Deleted Mice Has Higher Testosterone Level in the Testis During Pubertal Development.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Novel frameshift mutation of the NR0B1(DAX1) in two tall adult brothers.Molecular biology reports · 2019Article
- UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.RNA (New York, N.Y.) · 2019Review
- Regulatory processes that control haploid expression of salmon sperm mRNAs.BMC research notes · 2018Article
- Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.Chemical reviews · 2018Review
- FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.EMBO reports · 2016Article
- X-Linked Adrenal Hypoplasia Congenita in a Boy due to a Novel Deletion of the Entire NR0B1 (DAX1) and MAGEB1-4 Genes.International journal of endocrinology · 2016Article
- NR0B1 (DAX1) mutations in patients affected by congenital adrenal hypoplasia with growth hormone deficiency as a new finding.Journal of applied genetics · 2013Article
- Hypogonadotropic hypogonadism in subjects with DAX1 mutations.Molecular and cellular endocrinology · 2011Review
- Evidence of adrenal failure in aging Dax1-deficient mice.Endocrinology · 2011Article
- Regulation and expression of sexual differentiation factors in embryonic and extragonadal tissues of Atlantic salmon.BMC genomics · 2011Article
- DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression.The Journal of biological chemistry · 2009Article
- Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives.Molecular human reproduction · 2009Review
- Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.Molecular and cellular biology · 2009Article
- FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure.Nucleic acids research · 2009Article
- Article
- Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation.Reproductive biology and endocrinology : RB&E · 2007Article
- X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: report on new mutation of the DAX-1 gene in two siblings.Journal of endocrinological investigation · 2006Article
- Heat shock affects trafficking of DAX-1 by inducing its rapid and reversible cytoplasmic localization.Endocrine · 2005Article
- Orphan nuclear receptor DAX-1 in human endometrium and its disorders.Cancer science · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DAX-1 (NR0B1) gene encodes an unusual member of the nuclear hormone receptor superfamily which acts as a transcriptional repressor. Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita (AHC) associated with hypogonadotropic hypogonadism (HHG). We have studied the intracellular localization of the DAX-1 protein in human adrenal cortex and mouse Leydig tumor cells and found it to be both nuclear and cytoplasmic. A significant proportion of DAX-1 is associated with polyribosomes and is found complexed with polyadenylated RNA. DAX-1 directly binds to RNA, two domains within the protein being responsible for cooperative binding activity and specificity. Mutations in DAX-1 found in AHC-HHG patients significantly impair RNA binding. These findings reveal that DAX-1 plays multiple regulatory roles at the transcriptional and posttranscriptional levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.