ArticleMolecular and cellular biology2000
Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytes.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
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- MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes.Nature communications · 2019Article
- Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling.Cellular and molecular gastroenterology and hepatology · 2019Article
- Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis.Oncogene · 2016Article
- Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells.Journal of diabetes research · 2013Article
- Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?Archives of physiology and biochemistry · 2009Review
- Focal adhesion kinase regulates insulin resistance in skeletal muscle.Diabetologia · 2007Article
- PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes.Biochimica et biophysica acta · 2006Article
- Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways.The Biochemical journal · 2003Article
- Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes.Molecular and cellular biology · 2001Article
- D-chiro-inositol glycans in insulin signaling and insulin resistance.Molecular medicine (Cambridge, Mass.)Review
- Specific protein kinase C isoforms as transducers and modulators of insulin signaling.Molecular genetics and metabolismReview
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Signaling molecules downstream from the insulin receptor, such as the insulin receptor substrate protein 1 (IRS-1), are also activated by other receptor tyrosine kinases. Here we demonstrate that the non-receptor tyrosine kinases, focal adhesion kinase pp125(FAK) and Src-class kinase pp59(Lyn), after insulin-independent activation by phosphoinositolglycans (PIG), can cross talk to metabolic insulin signaling in rat and 3T3-L1 adipocytes. Introduction by electroporation of neutralizing antibodies against pp59(Lyn) and pp125(FAK) into isolated rat adipocytes blocked IRS-1 tyrosine phosphorylation in response to PIG but not insulin. Introduction of peptides encompassing either the major autophosphorylation site of pp125(FAK), tyrosine 397, or its regulatory loop with the twin tyrosines 576 and 577 inhibited PIG-induced IRS-1 tyrosine phosphorylation and glucose transport. PIG-induced pp59(Lyn) kinase activation and pp125(FAK) tyrosine phosphorylation were impaired by the former and latter peptide, respectively. Up-regulation of pp125(FAK) by integrin clustering diminished PIG-induced IRS-1 tyrosine phosphorylation and glucose transport in nonadherent but not adherent adipocytes. In conclusion, PIG induced IRS-1 tyrosine phosphorylation by causing (integrin antagonized) recruitment of IRS-1 and pp59(Lyn) to the common signaling platform molecule pp125(FAK), where cross talk of PIG-like structures and extracellular matrix proteins to metabolic insulin signaling may converge, possibly for the integration of the demands of glucose metabolism and cell architecture.
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