ArticleMolecular and cellular biology2000
Testing cyclin specificity in the exit from mitosis.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- A new linear cyclin docking motif that mediates exclusively S-phase CDK-specific signaling.The EMBO journal · 2021Article
- Article
- Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.Nature communications · 2018Article
- Transcriptional timing and noise of yeast cell cycle regulators-a single cell and single molecule approach.NPJ systems biology and applications · 2018Article
- Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.The Journal of biological chemistry · 2013Article
- Coordinated control of replication and transcription by a SAPK protects genomic integrity.Nature · 2013Article
- Cyclin regulation by the s phase checkpoint.The Journal of biological chemistry · 2010Article
- Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cyclin-specific control of ribosomal DNA segregation.Molecular and cellular biology · 2008Article
- Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.Molecular biology of the cell · 2008Article
- Article
- Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.Current biology : CB · 2007Article
- Bayesian Orthogonal Least Squares (BOLS) algorithm for reverse engineering of gene regulatory networks.BMC bioinformatics · 2007Article
- Article
- Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells.Eukaryotic cell · 2007Article
- Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.Molecular and cellular biology · 2007Article
- Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Molecular and cellular biology · 2006Article
- Integrative analysis of cell cycle control in budding yeast.Molecular biology of the cell · 2004Article
- Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclical inactivation of B-type cyclins has been proposed to be required for alternating DNA replication and mitosis. Destruction box-dependent Clb5p degradation is strongly increased in mitotic cells, and constitutive overexpression of Clb5p lacking the destruction box resulted in rapid accumulation of inviable cells, frequently multiply budded, with DNA contents ranging from unreplicated to apparently fully replicated. Loss of viability correlated with retention of nuclear Clb5p at the time of nuclear division. CLB2-Deltadb overexpression that was quantitatively comparable to CLB5-Deltadb overexpression with respect to Clb protein production and Clb-associated kinase activity resulted in a distinct phenotype: reversible mitotic arrest with uniformly replicated DNA. Simultaneous overexpression of CLB2-Deltadb and CLB5-Deltadb overexpressers similarly resulted in a uniform arrest with replicated DNA, and this arrest was significantly more reversible than that observed with CLB5-Deltadb overexpression alone. These results suggest that Clb2p and not Clb5p can efficiently block mitotic completion. We speculate that CLB5-Deltadb overexpression may be lethal, because persistence of high nuclear Clb5p-associated kinase throughout mitosis leads to failure to load origins of replication, thus preventing DNA replication in the succeeding cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.