Inflated false-positive rates in Hardy-Weinberg and linkage-equilibrium tests are due to sampling on the basis of rare familial phenotypes in finite populations.

What it found

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The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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Who cites it

7 citing papers in PubMed.

1. Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea.The pharmacogenomics journal · 2007
   Trial
2. Hardy-Weinberg Equilibrium in Meta-Analysis Studies and Large-Scale Genomic Sequencing Era.Asian Pacific journal of cancer prevention : APJCP · 2024
   Review
3. Effect of FTO Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population.Genetics & epigenetics · 2014
   Article
4. Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study.BMC medical genetics · 2010
   Article
5. Genome-wide autozygosity mapping in human populations.Genetic epidemiology · 2009
   Article
6. Complex and segmental uniparental disomy (UPD): review and lessons from rare chromosomal complements.Journal of medical genetics · 2001
   Review
7. QTL fine mapping, in extreme samples of finite populations, for complex traits with familial correlation due to polygenes.American journal of human genetics · 2000
   Article

Corrections and comments

• Commented on by
  QTL fine mapping, in extreme samples of finite populations, for complex traits with familial correlation due to polygenes.2000
• Comment on
  Linkage strategies for genetically complex traits. I. Multilocus models.1990
• Comment on
  True and false positive peaks in genomewide scans: applications of length-biased sampling to linkage mapping.1997
• Comment on
  Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.1998
• Comment on
  A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.1999
• Comment on
  A coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms.2000
• Comment on
  QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations.2000
• Comment on
  Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.2000

Authors and funding

1 author.

Funding

Abstract

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