ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Probing fundamental aspects of synaptic transmission with strontium.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
What it found
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Who cites it
89 citing papers in PubMed, 149 citations in OpenAlex.
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- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Enhancement of parvalbumin interneuron-mediated neurotransmission in the retrosplenial cortex of adolescent mice following third trimester-equivalent ethanol exposure.Scientific reports · 2021Article
- Withdrawal from chronic ethanol exposure increases postsynaptic glutamate function of insular cortex projections to the rat basolateral amygdala.Neuropharmacology · 2020Article
- VGluT1 Deficiency Impairs Visual Attention and Reduces the Dynamic Range of Short-Term Plasticity at Corticothalamic Synapses.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Nicotine Increases Spontaneous Glutamate Release in the Rostromedial Tegmental Nucleus.Frontiers in neuroscience · 2020Article
- Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175Frontiers in systems neuroscience · 2020Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Strontium is capable of supporting synaptic transmission, but release is dramatically different from that evoked in calcium. By measuring presynaptic strontium levels, we gain insight into the actions of strontium, which has implications for the identification of molecules involved in different aspects of synaptic transmission. We examined presynaptic divalent levels and synaptic release at the granule cell to stellate cell synapse in mouse cerebellar slices. We find that the prolonged duration of release and paired-pulse facilitation in the presence of strontium can be accounted for by the slower removal of strontium from the presynaptic terminal. Phasic and delayed release are both driven by strontium less effectively than by calcium, indicating that a heightened sensitivity to strontium is not a feature of the binding sites involved in facilitation and delayed release. We also find that the cooperativity for phasic release is 1.7 for strontium compared with 3.2 for calcium, suggesting that differential binding may help to identify the calcium sensor involved in phasic release.
Indexed as
Identifiers
10844010PMC6772435W1483947092What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.