ArticleProceedings of the National Academy of Sciences of the United States of America2000
Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 154 citations in OpenAlex.
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- Dengue virus serotype 2 infection alters midgut and carcass gene expression in the Asian tiger mosquito, Aedes albopictus.PloS one · 2017Article
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- Immunity-related genes in Ixodes scapularis--perspectives from genome information.Frontiers in cellular and infection microbiology · 2014Review
- The Anopheles innate immune system in the defense against malaria infection.Journal of innate immunity · 2014Review
- The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito, Aedes aegypti.Insect science · 2013Article
- Interactions between Asaia, Plasmodium and Anopheles: new insights into mosquito symbiosis and implications in malaria symbiotic control.Parasites & vectors · 2013Article
- Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector.Future microbiology · 2013Review
- Antimicrobial properties of Anopheles albimanus pericardial cells.Cell and tissue research · 2013Article
- Gal4-based enhancer-trapping in the malaria mosquito Anopheles stephensi.G3 (Bethesda, Md.) · 2012Article
- Article
- Mosquito immune defenses against Plasmodium infection.Developmental and comparative immunology · 2010Review
- Generation, annotation, and analysis of ESTs from midgut tissue of adult female Anopheles stephensi mosquitoes.BMC genomics · 2009Article
- Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites.PLoS pathogens · 2009Article
- Article
- Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites.The Journal of biological chemistry · 2009Article
- Article
- From Tucson to genomics and transgenics: the vector biology network and the emergence of modern vector biology.PLoS neglected tropical diseases · 2009Article
- Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite limited. We have conducted a pilot gene discovery project to accelerate progress in the molecular analysis of vector biology, with emphasis on the mosquito's antimalarial immune defense. A total of 5,925 expressed sequence tags were determined from normalized cDNA libraries derived from immune-responsive hemocyte-like cell lines. The 3,242 expressed sequence tag-containing cDNA clones were grouped into 2,380 clone clusters, potentially representing unique genes. Of these, 1,118 showed similarities to known genes from other organisms, but only 27 were identical to previously known mosquito genes. We identified 38 candidate genes, based on sequence similarity, that may be implicated in immune reactions including antimalarial defense; 19 of these were shown experimentally to be inducible by bacterial challenge, lending support to their proposed involvement in mosquito immunity.
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