ArticleProceedings of the National Academy of Sciences of the United States of America2000
Do lampreys have lymphocytes? The Spi evidence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Pancreatic Lymphatics in Health and Disease: Evolution, Embryology, and Neural Control.Lymphatics · 2026Article
- MHC Class I Regulation: The Origin Perspective.Cancers · 2020Article
- Diversity of Immunoglobulin (Ig) Isotypes and the Role of Activation-Induced Cytidine Deaminase (AID) in Fish.Molecular biotechnology · 2018Review
- Lamprey: a model for vertebrate evolutionary research.Zoological research · 2016Review
- Two Virus-Induced MicroRNAs Known Only from Teleost Fishes Are Orthologues of MicroRNAs Involved in Cell Cycle Control in Humans.PloS one · 2015Article
- The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system.American journal of physiology. Cell physiology · 2013Review
- Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates.Current genomics · 2012Article
- Reconstructing immune phylogeny: new perspectives.Nature reviews. Immunology · 2005Review
- Organization, alternative splicing, polymorphism, and phylogenetic position of lamprey CD45 gene.Immunogenetics · 2005Article
- The descent of the antibody-based immune system by gradual evolution.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
- Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Identification and characterization of a TAP-family gene in the lamprey.Immunogenetics · 2003Article
- Isolation and characterization of lymphocyte-like cells from a lamprey.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Spi-B can functionally replace PU.1 in myeloid but not lymphoid development.The EMBO journal · 2002Article
- Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- 50 million years of chordate evolution: seeking the origins of adaptive immunity.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that living jawless vertebrates (lampreys and hagfishes) lack the capability of mounting an adaptive immune response. At the same time, however, there are reports describing histological evidence for the presence in agnathan tissues of lymphocytes, the key players in adaptive immunity. The question therefore arises whether the cells identified morphologically as lymphocytes are true lymphocytes in terms of their genetic developmental program. In this study, evidence is provided that the lampreys express a member of the purine box 1 (PU.1)/spleen focus-forming virus integration B (Spi-B) gene family known to be critically and specifically involved in the differentiation of lymphocytes in jawed vertebrates. The lamprey gene is expressed in the lymphocyte-like cells of the digestive tract and inexplicably also in the ovary.
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