ReviewMolecular and cellular biochemistry2000
Anti-diabetic and toxic effects of vanadium compounds.
Review in Molecular and cellular biochemistry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 141 citations in OpenAlex.
- A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Exploring the Biological Effects of Anti-Diabetic Vanadium Compounds in the Liver, Heart and Brain.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Vanadium Compounds with Antidiabetic Potential.International journal of molecular sciences · 2023Review
- In Vitro, Oral Acute, and Repeated 28-Day Oral Dose Toxicity of a Mixed-Valence Polyoxovanadate Cluster.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats.Materials (Basel, Switzerland) · 2022Article
- Cardio-protective effects of a dioxidovanadium(V) complex in male sprague-dawley rats with streptozotocin-induced diabetes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Vanadium-protein complex inhibits human adipocyte differentiation through the activation of β-catenin and LKB1/AMPK signaling pathway.PloS one · 2020Article
- Selenium, Vanadium, and Chromium as Micronutrients to Improve Metabolic Syndrome.Current hypertension reports · 2017Review
- Novel Vanadium-Loaded Ordered Collagen Scaffold Promotes Osteochondral Differentiation of Bone Marrow Progenitor Cells.International journal of biomaterials · 2016Article
- Effect of aerobic exercise against vanadyl sulphate-induced nephrotoxicity and hepatotoxicity in rats.Journal of renal injury prevention · 2016Article
- Vanadium compounds in medicine.Coordination chemistry reviews · 2015Review
- Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans.Journal of clinical & cellular immunology · 2015Article
- Vanadium methyl-bipyridine organoligand and its influence on energy balance and organs mass.Biological trace element research · 2014Article
- Vanadium as a chemoprotectant: effect of vanadium(III)-L-cysteine complex against cyclophosphamide-induced hepatotoxicity and genotoxicity in Swiss albino mice.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- Ameliorative effect of vanadium on oxidative stress in stomach tissue of diabetic rats.Bosnian journal of basic medical sciences · 2014Article
- Vanadyl sulfate treatment stimulates proliferation and regeneration of beta cells in pancreatic islets.Journal of diabetes research · 2014Article
- Alternative therapies for diabetes and its cardiac complications: role of vanadium.Heart failure reviews · 2014Review
- Trace elements in diabetic cardiomyopathy: An electrophysiological overview.World journal of diabetes · 2013Article
- Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells.Investigational new drugs · 2012Article
- Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.Evidence-based complementary and alternative medicine : eCAM · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compounds of the trace element vanadium have been shown to mimic insulin in in vitro and in vivo systems. These compounds have been found to exert anti-diabetic effects in rodent models of type 1 and type 2 diabetes mellitus as well as in a limited number of studies in human diabetic subjects. Thus, vanadium compounds have emerged as agents for potential use in diabetes therapy. However, treatment of diabetic animals with inorganic vanadium salts has also been associated with some toxic side-effects such as gastrointestinal discomfort and decreased body weight gain. In addition, vanadium salts have been reported to exert toxic effects on the liver and kidney. More recently, it was shown that organic vanadium compounds were much safer than inorganic vanadium salts and did not cause any gastrointestinal discomfort, hepatic or renal toxicity. This review briefly summarizes the anti-diabetic and toxic effects of vanadium compounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.