Trial reportMolecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology2000
Detection of circulating epithelial cells after surgery for benign breast disease.
Trial report in Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Cytology and cell-block immunohistochemistry of circulating tumour cells.Cytopathology : official journal of the British Society for Clinical Cytology · 2019Article
- Technologies for circulating tumor cell separation from whole blood.Journal of hematology & oncology · 2019Review
- Circulating tumor cell technologies.Molecular oncology · 2016Review
- DNA methylation as a potential diagnosis indicator for rapid discrimination of rare cancer cells and normal cells.Scientific reports · 2015Article
- Nanotheranostics of circulating tumor cells, infections and other pathological features in vivo.Molecular pharmaceutics · 2013Review
- The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients.British journal of cancer · 2009Article
- Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer.Gynecologic oncology · 2009Article
- Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor.Journal of the American Chemical Society · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytokeratins are predominantly expressed in epithelial cells and their malignant counterparts. Ultrasensitive methods for cytokeratin messenger RNAs (mRNAs) can detect rare circulating tumor cells consistent with hematogenous dissemination in epithelial-derived malignancies, including breast carcinomas. Intraoperative tumor-cell shedding may contribute to this process; this hypothesis is based on the assumption that only tumor cells can be mobilized during surgical manipulation. METHODS AND
resultsThe present study addresses this issue by using cytokeratin 19 mRNA detection by reverse transcription-polymerase chain reaction (RT-PCR) in preoperative and postoperative blood samples from 54 patients undergoing excisional biopsy for benign breast disease; 22 healthy volunteers represented the control group. No cytokeratin RT-PCR positivity was found in the control or preoperative samples. Cytokeratin RT-PCR positivity was found in 21 postoperative samples (39%).
conclusionsThis finding shows that benign epithelial cells can be mobilized during breast surgery; this effect of surgical manipulation warrants caution in the interpretation of RT-PCR positivity for cytokeratin mRNA in the peripheral blood of patients undergoing surgery for breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.