ArticleRNA (New York, N.Y.)2000
Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.
Article in RNA (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Investigating the Activities ofBiology · 2024Article
- The contribution and therapeutic implications of IGHMBP2 mutations on IGHMBP2 biochemical activity and ABT1 association.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- The RNA helicases Dbp2 and Mtr4 regulate the expression of Xrn1-sensitive long non-coding RNAs in yeast.Frontiers in RNA research · 2023Article
- Review
- A yeast model of FUS/TLS-dependent cytotoxicity.PLoS biology · 2011Article
- The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.PloS one · 2011Article
- Eukaryotic release factor 1-2 affects Arabidopsis responses to glucose and phytohormones during germination and early seedling development.Journal of experimental botany · 2010Article
- Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].Molecular biology of the cell · 2009Article
- Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.The EMBO journal · 2008Article
- Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.Plant physiology · 2005Article
- Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability.Molecular and cellular biology · 2005Article
- The major 5' determinant in stop codon read-through involves two adjacent adenines.Nucleic acids research · 2004Article
- Assessing functional divergence in EF-1alpha and its paralogs in eukaryotes and archaebacteria.Nucleic acids research · 2003Article
- Termination of translation: interplay of mRNA, rRNAs and release factors?The EMBO journal · 2003Review
- Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae.Genetics · 2002Article
- Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation.Molecular and cellular biology · 2002Article
- Novel non-Mendelian determinant involved in the control of translation accuracy in Saccharomyces cerevisiae.Genetics · 2002Article
- Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Molecular and cellular biology · 2001Article
- Nonsense-mediated decay of human HEXA mRNA.Molecular and cellular biology · 2001Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
Translation termination is the final step that completes the synthesis of a polypeptide. Premature translation termination by introduction of a nonsense mutation leads to the synthesis of a truncated protein. We report the identification and characterization of the product of the MTT1 gene, a helicase belonging to the Upfl-like family of helicases that is involved in modulating translation termination. MTT1 is homologous to UPF1, a factor previously shown to function in both mRNA turnover and translation termination. Overexpression of MTT1 induced a nonsense suppression phenotype in a wild-type yeast strain. Nonsense suppression is apparently not due to induction of [PSI+], even though cooverexpression of HSP104 alleviated the nonsense suppression phenotype observed in cells overexpressing MTT1, suggesting a more direct role of Hsp104p in the translation termination process. The MTT1 gene product was shown to interact with translation termination factors and is localized to polysomes. Taken together, these results indicate that at least two members of a family of RNA helicases modulate translation termination efficiency in cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.