ArticleThe European respiratory journal1999
Allergen challenge-induced acute exudation of IL-8, ECP and alpha2-macroglobulin in human rhinovirus-induced common colds.
Article in The European respiratory journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis.Respiratory research · 2012Trial
- LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects.Respiratory medicine · 2011Trial
- Early humoral defence: Contributing to confining COVID-19 to conducting airways?Scandinavian journal of immunology · 2021Review
- Humoral First-Line Mucosal Innate Defence in vivo.Journal of innate immunity · 2020Review
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages.The Journal of allergy and clinical immunology · 2014Article
- Article
- Detection of respiratory viruses in adult patients with perennial allergic rhinitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Persistent airway obstruction after virus infection is not associated with airway inflammation.Chest · 2007Article
- Defensin and chemokine expression patterns in the palatine tonsil: a model of their local interaction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2006Article
- Mechanisms of rhinovirus-induced asthma.Paediatric respiratory reviews · 2004Review
- An adult model of exclusive viral wheeze: inflammation in the upper and lower respiratory tracts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2003Article
- Rhinoviruses in the pathogenesis of asthma.Current allergy and asthma reports · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhinovirus infections cause exacerbations of eosinophilic airway disease. The acute effects of allergen-challenge on nasal interleukin-8 (IL-8), eosinophil cationic protein (ECP), and alpha2-macroglobulin were examined in atopic subjects with common cold symptoms. Twenty-three patients with seasonal allergic rhinitis were inoculated with human rhinovirus 16 outside the pollen season. Diluent and allergen challenges, followed by nasal lavages, were carried out about 3 months before and 4 days after virus inoculation. Seventeen patients developed significant common cold symptoms with increased nasal lavage fluid levels of alpha2-macroglobulin, IL-8, and ECP at baseline (p<0.001-0.05 versus before inoculation), and were further increased by allergen challenge (p< 0.001-0.05); IL-8 and ECP levels were correlated (r = 0.63, p<0.001). Before inoculation, the six patients who later did not develop common cold symptoms had high levels of IL-8 and myeloperoxidase (MPO), and exhibited strong allergen-induced plasma exudation responses (alpha2-macroglobulin). After inoculation, IL-8 and ECP did not increase in these symptomless subjects. In conclusion, high nasal interleukin-8 and myeloperoxidase levels and exudative hyperresponsiveness may protect against infection. The association between nasal interleukin-8 and eosinophil cationic protein in common cold, particularly that observed in nasal lavage fluids after allergen-induced acute exudation of plasma, suggests the involvement of interleukin-8 in exacerbation of airway mucosal eosinophil activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.